國立高雄大學圖資館 |

Language: English

Back

Radiobiology of glioblastomarecent a...

Giordano, Antonio.

Radiobiology of glioblastomarecent advances and related pathobiology /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Radiobiology of glioblastomaedited by Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano.
Reminder of title:	recent advances and related pathobiology /
other author:	Pirtoli, Luigi.
Published:	Cham :Springer International Publishing :2016.
Description:	xx, 305 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Glioblastoma multiformeRadiotherapy.
Online resource:	http://dx.doi.org/10.1007/978-3-319-28305-0
ISBN:	9783319283050$q(electronic bk.)

Radiobiology of glioblastomarecent advances and related pathobiology /
Radiobiology of glioblastomarecent advances and related pathobiology /[electronic resource] :edited by Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano. - Cham :Springer International Publishing :2016. - xx, 305 p. :ill., digital ;24 cm. - Current clinical pathology,2197-781X. - Current clinical pathology..

Introduction and Background -- The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options -- Radiobiological Hints from Clinical Studies -- Chemo-radiotherapy: Radiation Total Dose and Fractionation -- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy -- Mathematical Modeling of Radiobiological Parameters from Clinical Studies -- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series -- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond -- Basic Knowledge of Glioblastoma Radiobiology -- Molecular Radiobiology and Mathematical Modeling -- Genetic and Epigenetic Determinants in Tumor Initiation and Progression -- Tumor Microenvironment -- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy -- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models -- Glioma Stem-like Cells and Radiation Resistance -- Hypoxia and Radiation Resistance -- Invasiveness and Radiation Failures -- Nanoparticle Technology for Research Radiobiology -- The Molecular Classification of Glioblastoma as a Translational Instrument -- Translational Perspectives for Gene Therapy -- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods -- From Molecular to Clinical Radiation Biology -- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results -- Conclusive Remarks and Perspectives for Future Research.

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.

ISBN: 9783319283050$q(electronic bk.)

Standard No.: 10.1007/978-3-319-28305-0doiSubjects--Topical Terms:

750355
Glioblastoma multiforme
--Radiotherapy.

LC Class. No.: RC280.B7

Dewey Class. No.: 616.99480642

Radiobiology of glioblastomarecent advances and related pathobiology /
LDR:04043nmm a2200325 a 4500 001 490774
003 DE-He213
005 20161130132007.0
006 m d
007 cr nn 008maaau
008 170118s2016 gw s 0 eng d
020 $a 9783319283050$q(electronic bk.)
020 $a 9783319283036$q(paper)
024 7 $a 10.1007/978-3-319-28305-0 $2 doi
035 $a 978-3-319-28305-0
040 $a GP $c GP
041 0 $a eng
050 4 $a RC280.B7
072 7 $a MMF $2 bicssc
072 7 $a MED067000 $2 bisacsh
082 0 4 $a 616.99480642 $2 23
090 $a RC280.B7 $b R129 2016
245 0 0 $a Radiobiology of glioblastoma $h [electronic resource] : $b recent advances and related pathobiology / $c edited by Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano.
260 $a Cham : $b Springer International Publishing : $b Imprint: Humana Press, $c 2016.
300 $a xx, 305 p. : $b ill., digital ; $c 24 cm.
490 1 $a Current clinical pathology, $x 2197-781X
505 0 $a Introduction and Background -- The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options -- Radiobiological Hints from Clinical Studies -- Chemo-radiotherapy: Radiation Total Dose and Fractionation -- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy -- Mathematical Modeling of Radiobiological Parameters from Clinical Studies -- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series -- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond -- Basic Knowledge of Glioblastoma Radiobiology -- Molecular Radiobiology and Mathematical Modeling -- Genetic and Epigenetic Determinants in Tumor Initiation and Progression -- Tumor Microenvironment -- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy -- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models -- Glioma Stem-like Cells and Radiation Resistance -- Hypoxia and Radiation Resistance -- Invasiveness and Radiation Failures -- Nanoparticle Technology for Research Radiobiology -- The Molecular Classification of Glioblastoma as a Translational Instrument -- Translational Perspectives for Gene Therapy -- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods -- From Molecular to Clinical Radiation Biology -- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results -- Conclusive Remarks and Perspectives for Future Research.
520 $a This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.
650 0 $a Glioblastoma multiforme $x Radiotherapy. $3 750355
650 0 $a Radiobiology. $3 195423
650 1 4 $a Medicine & Public Health. $3 273799
650 2 4 $a Pathology. $3 196513
650 2 4 $a Oncology. $3 195181
700 1 $a Pirtoli, Luigi. $3 750353
700 1 $a Gravina, Giovanni Luca. $3 750354
700 1 $a Giordano, Antonio. $3 357476
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Current clinical pathology. $3 558894
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-28305-0
950 $a Medicine (Springer-11650)