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Protein tyrosine phosphatases in cancer

Neel, Benjamin G.

Protein tyrosine phosphatases in cancer

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Protein tyrosine phosphatases in canceredited by Benjamin G. Neel, Nicholas K. Tonks.
其他作者:	Neel, Benjamin G.
出版者:	New York, NY :Springer New York :2016.
面頁冊數:	viii, 360 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
標題:	CancerMolecular aspects.
電子資源:	http://dx.doi.org/10.1007/978-1-4939-3649-6
ISBN:	9781493936496$q(electronic bk.)

Protein tyrosine phosphatases in cancer
Protein tyrosine phosphatases in cancer[electronic resource] /edited by Benjamin G. Neel, Nicholas K. Tonks. - New York, NY :Springer New York :2016. - viii, 360 p. :ill. (some col.), digital ;24 cm.

1 Introduction to the PTP Superfamily -- 2 Receptor PTPs in Cancer -- 3 Non-Receptor PTPs in Cancer -- 4 HP2 -- 5 C-PTP -- 6 PTP1B -- 7 PTP-PEST -- 8 Dual Specificity Phosphatases in Cancer -- 9 Phosphatase-dependent roles for PTEN in Cancer -- 10 Phosphatase-independent roles for PTEN in Cancer -- 11 PRL family members in Cancer -- 12 Cdc25 family -- 13 PTPs, metabolism and cancer -- 14 PTPs, metabolism and cancer -- 15 Current status of PTP-based therapeutics -- 16 Summary and Perspective.

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer, from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.

ISBN: 9781493936496$q(electronic bk.)

Standard No.: 10.1007/978-1-4939-3649-6doiSubjects--Topical Terms:

221221
Cancer
--Molecular aspects.

LC Class. No.: RC262

Dewey Class. No.: 616.994

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505 0 $a 1 Introduction to the PTP Superfamily -- 2 Receptor PTPs in Cancer -- 3 Non-Receptor PTPs in Cancer -- 4 HP2 -- 5 C-PTP -- 6 PTP1B -- 7 PTP-PEST -- 8 Dual Specificity Phosphatases in Cancer -- 9 Phosphatase-dependent roles for PTEN in Cancer -- 10 Phosphatase-independent roles for PTEN in Cancer -- 11 PRL family members in Cancer -- 12 Cdc25 family -- 13 PTPs, metabolism and cancer -- 14 PTPs, metabolism and cancer -- 15 Current status of PTP-based therapeutics -- 16 Summary and Perspective.
520 $a This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer, from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.
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