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Defects in T cell trafficking and re...

Donnadieu, Emmanuel.

Defects in T cell trafficking and resistance to cancer immunotherapy

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Defects in T cell trafficking and resistance to cancer immunotherapyedited by Emmanuel Donnadieu.
其他作者:	Donnadieu, Emmanuel.
出版者:	Cham :Springer International Publishing :2016.
面頁冊數:	viii, 199 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	CancerImmunotherapy.
電子資源:	http://dx.doi.org/10.1007/978-3-319-42223-7
ISBN:	9783319422237$q(electronic bk.)

Defects in T cell trafficking and resistance to cancer immunotherapy
Defects in T cell trafficking and resistance to cancer immunotherapy[electronic resource] /edited by Emmanuel Donnadieu. - Cham :Springer International Publishing :2016. - viii, 199 p. :ill., digital ;24 cm. - Resistance to targeted anti-cancer therapeutics,2196-5501. - Resistance to targeted anti-cancer therapeutics..

Introduction -- Basic rules of T cell migration -- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging -- Vascular normalization, T cell trafficking and anti-tumor immunity -- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts -- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic -- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy -- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors -- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors.

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

ISBN: 9783319422237$q(electronic bk.)

Standard No.: 10.1007/978-3-319-42223-7doiSubjects--Topical Terms:

201873
Cancer
--Immunotherapy.

LC Class. No.: RC271.I45

Dewey Class. No.: 616.99406

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