國立高雄大學圖資館 |

語系: 繁體中文

說明(常見問題)

圖資館首頁

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Study of the calcium regulation mech...

Bi, Yunchen.

Study of the calcium regulation mechanism of TCR activation using nanodisc and NMR technologies

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Study of the calcium regulation mechanism of TCR activation using nanodisc and NMR technologiesby Yunchen Bi.
作者:	Bi, Yunchen.
出版者:	Berlin, Heidelberg :Springer Berlin Heidelberg :2018.
面頁冊數:	xii, 79 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	CalciumMetabolism
電子資源:	http://dx.doi.org/10.1007/978-3-662-54618-5
ISBN:	9783662546185$q(electronic bk.)

Study of the calcium regulation mechanism of TCR activation using nanodisc and NMR technologies
Bi, Yunchen.

Study of the calcium regulation mechanism of TCR activation using nanodisc and NMR technologies[electronic resource] /by Yunchen Bi. - Berlin, Heidelberg :Springer Berlin Heidelberg :2018. - xii, 79 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Review -- Nanodisc assembly and the study on the interaction between the lipid and ion -- Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation -- The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin -- Summary and prospect of this dissertation.

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.

ISBN: 9783662546185$q(electronic bk.)

Standard No.: 10.1007/978-3-662-54618-5doiSubjects--Topical Terms:

799254
Calcium
--Metabolism

LC Class. No.: QP535.C2

Dewey Class. No.: 572.516

Study of the calcium regulation mechanism of TCR activation using nanodisc and NMR technologies
LDR:02255nmm a2200325 a 4500 001 526601
003 DE-He213
005 20170620093917.0
006 m d
007 cr nn 008maaau
008 181012s2018 gw s 0 eng d
020 $a 9783662546185$q(electronic bk.)
020 $a 9783662546161$q(paper)
024 7 $a 10.1007/978-3-662-54618-5 $2 doi
035 $a 978-3-662-54618-5
040 $a GP $c GP
041 0 $a eng
050 4 $a QP535.C2
072 7 $a MQW $2 bicssc
072 7 $a TEC009000 $2 bisacsh
082 0 4 $a 572.516 $2 23
090 $a QP535.C2 $b B576 2018
100 1 $a Bi, Yunchen. $3 799253
245 1 0 $a Study of the calcium regulation mechanism of TCR activation using nanodisc and NMR technologies $h [electronic resource] / $c by Yunchen Bi.
260 $a Berlin, Heidelberg : $b Springer Berlin Heidelberg : $b Imprint: Springer, $c 2018.
300 $a xii, 79 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Introduction -- Review -- Nanodisc assembly and the study on the interaction between the lipid and ion -- Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation -- The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin -- Summary and prospect of this dissertation.
520 $a This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.
650 0 $a Calcium $x Metabolism $x Regulation. $3 799254
650 0 $a T cells $x Receptors. $3 308634
650 0 $a Nuclear magnetic resonance. $3 203350
650 0 $a CD antigens. $3 799255
650 0 $a Dengue viruses. $3 594634
650 1 4 $a Engineering. $3 210888
650 2 4 $a Biomedical Engineering. $3 190464
650 2 4 $a Biological and Medical Physics, Biophysics. $3 759746
650 2 4 $a Membrane Biology. $3 384426
650 2 4 $a Immunology. $3 189152
650 2 4 $a Atomic/Molecular Structure and Spectra. $3 455686
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Springer theses. $3 557607
856 4 0 $u http://dx.doi.org/10.1007/978-3-662-54618-5
950 $a Engineering (Springer-11647)