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Structural and biochemical character...

Brauning, Bastian.

Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocoliticaby Bastian Brauning.
作者:	Brauning, Bastian.
出版者:	Cham :Springer International Publishing :2019.
面頁冊數:	xxxi, 86 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Toxins.
電子資源:	https://doi.org/10.1007/978-3-030-29439-7
ISBN:	9783030294397$q(electronic bk.)

Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica
Brauning, Bastian.

Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica[electronic resource] /by Bastian Brauning. - Cham :Springer International Publishing :2019. - xxxi, 86 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Objectives -- Materials & Methods -- Results -- Discussion.

This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families. Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Brauning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts.

ISBN: 9783030294397$q(electronic bk.)

Standard No.: 10.1007/978-3-030-29439-7doiSubjects--Topical Terms:

193790
Toxins.

LC Class. No.: QP631 / .B786 2019

Dewey Class. No.: 615.95

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