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Carbohydrate-spiro-heterocycles

Somsak, Laszlo.

Carbohydrate-spiro-heterocycles

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Carbohydrate-spiro-heterocyclesedited by Laszlo Somsak.
其他作者:	Somsak, Laszlo.
出版者:	Cham :Springer International Publishing :2019.
面頁冊數:	vii, 295 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Heterocyclic compounds.
電子資源:	https://doi.org/10.1007/978-3-030-31942-7
ISBN:	9783030319427$q(electronic bk.)

Carbohydrate-spiro-heterocycles
Carbohydrate-spiro-heterocycles[electronic resource] /edited by Laszlo Somsak. - Cham :Springer International Publishing :2019. - vii, 295 p. :ill., digital ;24 cm. - Topics in heterocyclic chemistry,571861-9282 ;. - Topics in heterocyclic chemistry ;v.27..

Anomeric Spiro-Annulated Glycopyranosides: An Overview of Synthetic Methodologies and Biological Applications -- Cycloaddition Reactions of Sugar-Based Olefins, Nitrones and Nitrile Oxides: En Route to Saccharidic Spiroisoxazoli(di)nes -- Carbohydrate Spiro-heterocycles via Radical Chemistry -- Carbohydrate-Derived Spiroketals and Spirocyclic Lactones -- Cyanohydrins and Aminocyanides as Key Intermediates to Various Spiroheterocyclic Sugars -- Recent Advances in the Chemistry and Biology of Spirocyclic Nucleosides -- Spiroketal Phthalane C-Glycosides: Synthesis of Papulacandins and SGLT2 Inhibitors -- Spiro Iminosugars: Structural Diversity and Synthetic Strategies.

This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.

ISBN: 9783030319427$q(electronic bk.)

Standard No.: 10.1007/978-3-030-31942-7doiSubjects--Topical Terms:

235305
Heterocyclic compounds.

LC Class. No.: QD400.3 / .C373 2019

Dewey Class. No.: 547.59

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520 $a This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.
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