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Uremic toxins and organ failure

Abe, Takaaki.

Uremic toxins and organ failure

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Uremic toxins and organ failureedited by Hideyuki Saito, Takaaki Abe.
其他作者:	Saito, Hideyuki.
出版者:	Singapore :Springer Singapore :2020.
面頁冊數:	viii, 180 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Uremia.
電子資源:	https://doi.org/10.1007/978-981-15-7793-2
ISBN:	9789811577932$q(electronic bk.)

Uremic toxins and organ failure
Uremic toxins and organ failure[electronic resource] /edited by Hideyuki Saito, Takaaki Abe. - Singapore :Springer Singapore :2020. - viii, 180 p. :ill. (some col.), digital ;24 cm.

1 Overview of Uremic Toxins -- 2 Review: Uremic toxins and gut microbiome -- 3 Gut microbiota and systemic uremic solute accumulation -- 4 Uremic toxin-related systemic disorders -- 5 Uremic Toxins and cardiovascular disease -- 6 Indoxyl sulfate and arteriosclerosis -- 7 Uremic Toxicity and Bone in CKD -- 8 D-serine as a novel uremic toxin -- 9 Uremic solutes and sarcopenia -- 10 Toxico-pathological role of hepatic sulfotransferase (SULT) 1A1 in acute kidney injuries -- 11 Accumulation of uremic toxins in systemic organs and the effect of AST-120.

This book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.

ISBN: 9789811577932$q(electronic bk.)

Standard No.: 10.1007/978-981-15-7793-2doiSubjects--Topical Terms:

721375
Uremia.

LC Class. No.: RC915

Dewey Class. No.: 616.635

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520 $a This book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.
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