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Statistical design and analysis of b...

Kaltenbach, Hans-Michael.

Statistical design and analysis of biological experiments

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Statistical design and analysis of biological experimentsby Hans-Michael Kaltenbach.
作者:	Kaltenbach, Hans-Michael.
出版者:	Cham :Springer International Publishing :2021.
面頁冊數:	xiv, 269 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Experimental design.
電子資源:	https://doi.org/10.1007/978-3-030-69641-2
ISBN:	9783030696412$q(electronic bk.)

Statistical design and analysis of biological experiments
Kaltenbach, Hans-Michael.

Statistical design and analysis of biological experiments[electronic resource] /by Hans-Michael Kaltenbach. - Cham :Springer International Publishing :2021. - xiv, 269 p. :ill., digital ;24 cm. - Statistics for biology and health,1431-8776. - Statistics for biology and health..

Principles of Experimental Design -- Review of Statistical Concepts -- Planning for Precision and Power -- Comparing More than Two Groups -- Comparing Treatment Groups with Linear Contrasts -- Multiple Treatment Factors: Factorial Designs -- Improving Precision and Power: Blocked Designs -- Split-Unit Designs -- Many Treatment Factors: Fractional Factorial Designs -- Experimental Optimization with Response Surface Methods -- References -- Index.

This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including 'portable power' formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.

ISBN: 9783030696412$q(electronic bk.)

Standard No.: 10.1007/978-3-030-69641-2doiSubjects--Topical Terms:

181887
Experimental design.

LC Class. No.: QH316.5 / .K358 2021

Dewey Class. No.: 570.727

Statistical design and analysis of biological experiments
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520 $a This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including 'portable power' formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.
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