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Proteinkinase inhibitors

Laufer, Stefan.

Proteinkinase inhibitors

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Proteinkinase inhibitorsedited by Stefan Laufer.
其他作者:	Laufer, Stefan.
出版者:	Cham :Springer International Publishing :2021.
面頁冊數:	vii, 256 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
標題:	Protein kinasesInhibitors.
電子資源:	https://doi.org/10.1007/978-3-030-68180-7
ISBN:	9783030681807$q(electronic bk.)

Proteinkinase inhibitors
Proteinkinase inhibitors[electronic resource] /edited by Stefan Laufer. - Cham :Springer International Publishing :2021. - vii, 256 p. :ill., digital ;24 cm. - Topics in medicinal chemistry,361862-2461 ;. - Topics in medicinal chemistry ;8..

ProteinKinase-Inhibitors: A Story of Success -- Function, Structure and Topology of Proteinkinases -- Molecular Modelling -- Case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR -- Achieving high level of selectivity for kinase inhibitors -- Inhibitors of c-Jun N-terminal kinase 3 -- Exploiting kinase inhibitors for cancer treatment - An Overview of Clinical Results and Outlook -- Covalent Janus Kinase 3 Inhibitors.

This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book. Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike.

ISBN: 9783030681807$q(electronic bk.)

Standard No.: 10.1007/978-3-030-68180-7doiSubjects--Topical Terms:

873824
Protein kinases
--Inhibitors.

LC Class. No.: QP606.P76

Dewey Class. No.: 572.792

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