國立高雄大學圖資館 |

Language: English

Back

DNA chain dynamics and its applications to micro devices and scission.

Record Type:	Electronic resources : Monograph/item
Title/Author:	DNA chain dynamics and its applications to micro devices and scission.
Author:	Woo, Jung Ho.
Description:	204 p.
Notes:	Adviser: Eric S. G. Shaqfeh.
Notes:	Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2298.
Contained By:	Dissertation Abstracts International64-05B.
Subject:	Engineering, Chemical.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090706
ISBN:	0496384287

DNA chain dynamics and its applications to micro devices and scission.
Woo, Jung Ho.

DNA chain dynamics and its applications to micro devices and scission. [electronic resource] - 204 p.

Adviser: Eric S. G. Shaqfeh.

Thesis (Ph.D.)--Stanford University, 2003.

Finally, guided by the mixed flow study, we can predict typical DNA chain configurations in various mixed flows and we apply these findings to study the chain fragmentation process in a number of model flows including contraction flow. We confirm that previous literature estimates of the critical tension for chain scission is in good agreement with both our experiments and simulations and explain why different critical fracture rates are expected in different types of flows. Furthermore we apply this understanding to more complicated contraction flows with a number of design aspects in mind.

ISBN: 0496384287Subjects--Topical Terms:

226989
Engineering, Chemical.

DNA chain dynamics and its applications to micro devices and scission.
LDR:03190nmm _2200289 _450 001 162017
005 20051017073401.5
008 230606s2003 eng d
020 $a 0496384287
035 $a 00148518
035 $a 162017
040 $a UnM $c UnM
100 0 $a Woo, Jung Ho. $3 227120
245 1 0 $a DNA chain dynamics and its applications to micro devices and scission. $h [electronic resource]
300 $a 204 p.
500 $a Adviser: Eric S. G. Shaqfeh.
500 $a Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2298.
502 $a Thesis (Ph.D.)--Stanford University, 2003.
520 # $a Finally, guided by the mixed flow study, we can predict typical DNA chain configurations in various mixed flows and we apply these findings to study the chain fragmentation process in a number of model flows including contraction flow. We confirm that previous literature estimates of the critical tension for chain scission is in good agreement with both our experiments and simulations and explain why different critical fracture rates are expected in different types of flows. Furthermore we apply this understanding to more complicated contraction flows with a number of design aspects in mind.
520 # $a In the second half, we consider the application to DNA chain scission. Typical scission devices involve complicated flow fields which involve a variety of mixed flows. The tension induced in the chain by the flow is directly related to the chain conformation. Therefore, first, we examine the configurational phase transitions of flexible chains in mixed flows. As the flow type changes, the chain undergoes changes in configuration from the coiled state to the tumbling state and to non-tumbling extended state. We find these transitions are well characterized by the dispersion layer thickness in shear flow alone.
520 # $a Theoretical arguments suggest that the main consequences of confinement on chains are (a) the entropic force law is altered due to the loss of the chain configurational space, and (b) the viscous drag on the chain is increased due to hydrodynamic interactions (HI ) with the wall. The correct entropic spring force law and a new beadspring algorithm is developed in the presence of confining walls. We determine how the effective viscosity asymptotically approaches its bulk value. We also observe that the confinement results in two different measures of the chain relaxation time.
520 # $a We present various aspects of DNA chain dynamics related to micro devices and chain scission. In the first half, we consider applications to micro devices, which are typically of the size of DNA chains and confinement effects are important. We study the effect of confining walls on the rheology and dynamics of dilute DNA solutions using a self consistent multiscale simulation technique.
590 $a School code: 0212.
650 # 0 $a Engineering, Chemical. $3 226989
650 # 0 $a Biology, Molecular. $3 226919
710 0 # $a Stanford University. $3 212607
773 0 # $g 64-05B. $t Dissertation Abstracts International
790 $a 0212
790 1 0 $a Shaqfeh, Eric S. G., $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://libsw.nuk.edu.tw/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090706 $z http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090706