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Total synthesis of luminacin D, isopanepoxydone, panepoxydone, and an isopanepoxydone derived biotinylated affinity reagent.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Total synthesis of luminacin D, isopanepoxydone, panepoxydone, and an isopanepoxydone derived biotinylated affinity reagent.
Author:	Shotwell, John Bradford.
Description:	550 p.
Notes:	Directors: Craig M. Crews; John L. Wood.
Notes:	Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4950.
Contained By:	Dissertation Abstracts International64-10B.
Subject:	Chemistry, Organic.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3109462
ISBN:	0496570048

Total synthesis of luminacin D, isopanepoxydone, panepoxydone, and an isopanepoxydone derived biotinylated affinity reagent.
Shotwell, John Bradford.

Total synthesis of luminacin D, isopanepoxydone, panepoxydone, and an isopanepoxydone derived biotinylated affinity reagent. [electronic resource] - 550 p.

Directors: Craig M. Crews; John L. Wood.

Thesis (Ph.D.)--Yale University, 2003.

Bioactive natural products and their derivatives serve essential roles (i) as lead compounds in the development of new treatments for disease and (ii) as indispensable biochemical probes in the elucidation of new intracellular signaling pathways. Described herein are efficient total syntheses of the novel inhibitors of NF-kappaB signaling isopanepoxydone (91 ) and panepoxydone (2), in addition to the potent inhibitor of angiogenesis, luminacin D (180). These successful synthetic endeavors afforded not only usable quantities of these bioactive small molecules for subsequent biological investigations, but also served as a platform from which derivatization and molecular mode of action studies were launched.

ISBN: 0496570048Subjects--Topical Terms:

193634
Chemistry, Organic.

Total synthesis of luminacin D, isopanepoxydone, panepoxydone, and an isopanepoxydone derived biotinylated affinity reagent.
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245 1 0 $a Total synthesis of luminacin D, isopanepoxydone, panepoxydone, and an isopanepoxydone derived biotinylated affinity reagent. $h [electronic resource]
300 $a 550 p.
500 $a Directors: Craig M. Crews; John L. Wood.
500 $a Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4950.
502 $a Thesis (Ph.D.)--Yale University, 2003.
520 # $a Bioactive natural products and their derivatives serve essential roles (i) as lead compounds in the development of new treatments for disease and (ii) as indispensable biochemical probes in the elucidation of new intracellular signaling pathways. Described herein are efficient total syntheses of the novel inhibitors of NF-kappaB signaling isopanepoxydone (91 ) and panepoxydone (2), in addition to the potent inhibitor of angiogenesis, luminacin D (180). These successful synthetic endeavors afforded not only usable quantities of these bioactive small molecules for subsequent biological investigations, but also served as a platform from which derivatization and molecular mode of action studies were launched.
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650 # 0 $a Chemistry, Organic. $3 193634
650 # 0 $a Biology, Cell. $3 226967
650 # 0 $a Chemistry, Pharmaceutical. $3 206042
710 0 # $a Yale University. $3 212430
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790 1 0 $a Crews, Craig M., $e advisor
790 1 0 $a Wood, John L., $e advisor
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