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A synthesis strategy for generating diverse skeletons of small molecules combinatorially

Record Type:	Electronic resources : Monograph/item
Title/Author:	A synthesis strategy for generating diverse skeletons of small molecules combinatorially
Author:	Burke, Martin Damien.
Description:	305 p.
Notes:	Adviser: Stuart L. Schreiber.
Notes:	Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0221.
Contained By:	Dissertation Abstracts International65-01B.
Subject:	Chemistry, Organic.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3117973
ISBN:	0496653970

A synthesis strategy for generating diverse skeletons of small molecules combinatorially
Burke, Martin Damien.

A synthesis strategy for generating diverse skeletons of small molecules combinatorially [electronic resource] - 305 p.

Adviser: Stuart L. Schreiber.

Thesis (Ph.D.)--Harvard University, 2004.

*Please refer to dissertation for diagrams.

ISBN: 0496653970Subjects--Topical Terms:

193634
Chemistry, Organic.

A synthesis strategy for generating diverse skeletons of small molecules combinatorially
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245 1 2 $a A synthesis strategy for generating diverse skeletons of small molecules combinatorially $h [electronic resource]
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500 $a Adviser: Stuart L. Schreiber.
500 $a Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0221.
502 $a Thesis (Ph.D.)--Harvard University, 2004.
520 # $a *Please refer to dissertation for diagrams.
520 # $a Lack of efficient access to collections of synthetic compounds having skeletal diversity is a key bottleneck in the small-molecule discovery process. This thesis comprises the development and application of a potentially general synthesis strategy that involves transforming substrates having different appendages that pre-encode skeletal information, named sigma-elements, into products having different skeletons using common reaction conditions. With this approach, split-pool synthesis can be used to pre-encode skeletal information combinatorially, and thereby generate small molecules having distinct skeletons efficiently. This was demonstrated with the split-pool synthesis of &sim;1260 compounds representing overlapping, combinatorial matrices of molecular skeletons and appended building blocks in both enantiomeric and diastereomeric forms.*
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