國立高雄大學圖資館 |

Language: English

Back

The design, synthesis and evaluation of guanidine-based molecular transporters.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The design, synthesis and evaluation of guanidine-based molecular transporters.
Author:	Pattabiraman, Kanaka.
Description:	215 p.
Notes:	Adviser: Paul A. Wender.
Notes:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1873.
Contained By:	Dissertation Abstracts International65-04B.
Subject:	Chemistry, Organic.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3128681
ISBN:	0496759434

The design, synthesis and evaluation of guanidine-based molecular transporters.
Pattabiraman, Kanaka.

The design, synthesis and evaluation of guanidine-based molecular transporters.[electronic resource] - 215 p.

Adviser: Paul A. Wender.

Thesis (Ph.D.)--Stanford University, 2004.

Chapter 4 describes the efficient synthesis of the octaarginine homooligomer through a bidirectional approach in the solution phase. This synthesis enabled us to increase the scale and decrease the cost of synthesizing octaarginine relative to a solid phase approach on a peptide synthesizer.

ISBN: 0496759434Subjects--Topical Terms:

193634
Chemistry, Organic.

The design, synthesis and evaluation of guanidine-based molecular transporters.
LDR:02780nmm _2200325 _450 001 162651
005 20051017073509.5
008 230530s2004 eng d
020 $a 0496759434
035 $a 00149152
035 $a 162651
040 $a UnM $c UnM
100 0 $a Pattabiraman, Kanaka. $3 227795
245 1 4 $a The design, synthesis and evaluation of guanidine-based molecular transporters. $h [electronic resource]
300 $a 215 p.
500 $a Adviser: Paul A. Wender.
500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1873.
502 $a Thesis (Ph.D.)--Stanford University, 2004.
520 # $a Chapter 4 describes the efficient synthesis of the octaarginine homooligomer through a bidirectional approach in the solution phase. This synthesis enabled us to increase the scale and decrease the cost of synthesizing octaarginine relative to a solid phase approach on a peptide synthesizer.
520 # $a Chapter 5 describes recent efforts towards synthesizing bryostatin analogs that vary the C-21 unsaturated ester moiety.
520 # $a Chapters 2 and 3 outline our efforts towards synthesizing peptidomimetics that vary the spacing between either the backbone and the guanidine head group (peptoid analogs) or the spacing between guanidine head groups along the backbone (gamma peptide analogs). Both these modifications resulted in more efficient cellular uptake.
520 # $a The physical properties of many drugs and drug candidates prevent them from reaching their target in the body and therefore limit their clinical application. Biological barriers in the body such as the cell membrane pose a significant challenge for the delivery of therapeutics. It has been discovered that certain polar peptides are efficiently able to penetrate the cell membrane and enter cells. In particular, the basic domain of HIV-1 Tat has been shown to rapidly enter cells in an energy dependent fashion. It has been shown that the arginine residues of the Tat basic domain are responsible for its cellular uptake function and that short oligomers of arginine are able to cross the cell membrane and enter cells more efficiently than the parent Tat sequence. This thesis outlines some of our work towards understanding the relationship between structure and function of these arginine oligomers and towards applying this discovery to the delivery of therapeutics.
590 $a School code: 0212.
650 # 0 $a Chemistry, Organic. $3 193634
650 # 0 $a Chemistry, Biochemistry. $3 226900
650 # 0 $a Biology, Molecular. $3 226919
690 $a 0307
690 $a 0487
690 $a 0490
710 0 # $a Stanford University. $3 212607
773 0 # $g 65-04B. $t Dissertation Abstracts International
790 $a 0212
790 1 0 $a Wender, Paul A., $e advisor
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://libsw.nuk.edu.tw/login?url=http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3128681 $z http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3128681