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Part I. Highly diverse polyfluors o...

Gao, Jianmin.

Part I. Highly diverse polyfluors on a DNA-like backbone. Part II. Novel genetic system with expanded dimension: xDNA.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Part I. Highly diverse polyfluors on a DNA-like backbone. Part II. Novel genetic system with expanded dimension: xDNA.
Author:	Gao, Jianmin.
Description:	367 p.
Notes:	Adviser: Eric T. Kool.
Notes:	Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4576.
Contained By:	Dissertation Abstracts International65-09B.
Subject:	Chemistry, Organic.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3145510
ISBN:	0496044532

Part I. Highly diverse polyfluors on a DNA-like backbone. Part II. Novel genetic system with expanded dimension: xDNA.
Gao, Jianmin.

Part I. Highly diverse polyfluors on a DNA-like backbone. Part II. Novel genetic system with expanded dimension: xDNA. - 367 p.

Adviser: Eric T. Kool.

Thesis (Ph.D.)--Stanford University, 2004.

This thesis describes research on two separate projects. In the first project, a new class of water-soluble fluorescent molecules (polyfluors) was characterized. Polyfluors were constructed by replacing all the nucleobases in a single stranded DNA with fluorescent aromatic molecules. A combinatorial approach was established for the synthesis and screening of polyfluor libraries. The results revealed that these fluorophore oligomers exhibited highly diverse fluorescence properties. In addition, polyfluors are easily water-soluble and allow single wavelength excitation. All these features make them very promising to be used as fluorescent tags in chemical and biological applications. The second project describes a novel genetic helix with an expanded dimension. Replacing all the base pairs in native DNA with the size-expanded base pairs gave rise to a new genetic system with bigger size (xDNA). This novel genetic system was shown to function very similarly to natural DNA on the level of molecular recognition and self-assembly into higher order structures. Study of xDNA contributes to the better understanding of our genetic system. In addition, fluorescence of xDNA, together with the molecular recognition capability, may give rise to powerful molecular tools for biotechnological applications.

ISBN: 0496044532Subjects--Topical Terms:

193634
Chemistry, Organic.

Part I. Highly diverse polyfluors on a DNA-like backbone. Part II. Novel genetic system with expanded dimension: xDNA.
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245 1 0 $a Part I. Highly diverse polyfluors on a DNA-like backbone. Part II. Novel genetic system with expanded dimension: xDNA.
300 $a 367 p.
500 $a Adviser: Eric T. Kool.
500 $a Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4576.
502 $a Thesis (Ph.D.)--Stanford University, 2004.
520 # $a This thesis describes research on two separate projects. In the first project, a new class of water-soluble fluorescent molecules (polyfluors) was characterized. Polyfluors were constructed by replacing all the nucleobases in a single stranded DNA with fluorescent aromatic molecules. A combinatorial approach was established for the synthesis and screening of polyfluor libraries. The results revealed that these fluorophore oligomers exhibited highly diverse fluorescence properties. In addition, polyfluors are easily water-soluble and allow single wavelength excitation. All these features make them very promising to be used as fluorescent tags in chemical and biological applications. The second project describes a novel genetic helix with an expanded dimension. Replacing all the base pairs in native DNA with the size-expanded base pairs gave rise to a new genetic system with bigger size (xDNA). This novel genetic system was shown to function very similarly to natural DNA on the level of molecular recognition and self-assembly into higher order structures. Study of xDNA contributes to the better understanding of our genetic system. In addition, fluorescence of xDNA, together with the molecular recognition capability, may give rise to powerful molecular tools for biotechnological applications.
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