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Glutamate

Ottersen, O. P.

Glutamate

Record Type:	Electronic resources : Monograph/item
Title/Author:	Glutamateeditors, O.P. Ottersen and J. Storm-Mathisen.
other author:	Ottersen, O. P.
Published:	Amsterdam ;Elsevier,2000.
Description:	xvii, 291 p. :ill. ;27 cm.
Subject:	Glutamic acid.
Online resource:	http://www.sciencedirect.com/science/book/9780444502865
ISBN:	9780444502865

Glutamate
Glutamate[electronic resource] /editors, O.P. Ottersen and J. Storm-Mathisen. - 1st ed. - Amsterdam ;Elsevier,2000. - xvii, 291 p. :ill. ;27 cm. - Handbook of chemical neuroanatomy ;v. 18. - Handbook of chemical neuroanatomy ;v. 17..

Includes bibliographical references and index.

Biochemistry and anatomy of transmitter glutamate / J. Broman, B. Hassel, E. Rinvik and O.P. Ottersen -- Aspartate : neurochemical evidence for a transmitter role / V. Gundersen and J. Storm-Mathisen -- Metabotropic glutamate receptors : immunocytochemical and in situ hybridization analyses / R. Shigemoto and N. Mizuno -- AMPA, kainate and NMDA ionotropic glutamate receptor expression : an in situ hybridization atlas / W. Wisden, P.H. Seeburg and H. Monyer -- Regional and synaptic expression of ionotropic glutamate receptors / R.S. Petralia, M.E. Rubio, Y.-X. Wang and R.J. Wenthold -- Targeting and anchoring of glutamate receptors and associated signaling molecules / M. Wyszynski and M. Sheng -- Enzymes responsible for glutamate synthesis and degradation / T. Kaneko -- Sodium- and potassium-dependent excitatory amino acid transporters in brain plasma membranes / N.C. Danbolt -- Glutamate neurotransmission in the mammalian inner ear / S. Usami, A. Matsubara, S. Fujita, Y. Takumi and O.P. Ottersen -- A model glutamate synapse : the lamprey giant reticulospinal axon / O. Shupliakov and L. Brodin.

The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780444502865

Source: 122641:127407Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

274285
Glutamic acid.
Index Terms--Genre/Form:

214472
Electronic books.

LC Class. No.: QM451 / .H24 1983 vol. 18eb

Dewey Class. No.: 573.8/4

National Library of Medicine Call No.: W1 / HA51J v.18 2000

Glutamate
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300 $a xvii, 291 p. : $b ill. ; $c 27 cm.
490 1 $a Handbook of chemical neuroanatomy ; $v v. 18
504 $a Includes bibliographical references and index.
505 0 $a Biochemistry and anatomy of transmitter glutamate / J. Broman, B. Hassel, E. Rinvik and O.P. Ottersen -- Aspartate : neurochemical evidence for a transmitter role / V. Gundersen and J. Storm-Mathisen -- Metabotropic glutamate receptors : immunocytochemical and in situ hybridization analyses / R. Shigemoto and N. Mizuno -- AMPA, kainate and NMDA ionotropic glutamate receptor expression : an in situ hybridization atlas / W. Wisden, P.H. Seeburg and H. Monyer -- Regional and synaptic expression of ionotropic glutamate receptors / R.S. Petralia, M.E. Rubio, Y.-X. Wang and R.J. Wenthold -- Targeting and anchoring of glutamate receptors and associated signaling molecules / M. Wyszynski and M. Sheng -- Enzymes responsible for glutamate synthesis and degradation / T. Kaneko -- Sodium- and potassium-dependent excitatory amino acid transporters in brain plasma membranes / N.C. Danbolt -- Glutamate neurotransmission in the mammalian inner ear / S. Usami, A. Matsubara, S. Fujita, Y. Takumi and O.P. Ottersen -- A model glutamate synapse : the lamprey giant reticulospinal axon / O. Shupliakov and L. Brodin.
520 $a The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).
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