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Engineering nanoparticles surface fo...

Miranda-Sanchez, Oscar Ramon.

Engineering nanoparticles surface for biosensing: "Chemical noses" to detect and identify proteins, bacteria and cancerous cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Engineering nanoparticles surface for biosensing: "Chemical noses" to detect and identify proteins, bacteria and cancerous cells.
Author:	Miranda-Sanchez, Oscar Ramon.
Description:	310 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: .
Notes:	Adviser: Vincent M. Rotello.
Contained By:	Dissertation Abstracts International72-05B.
Subject:	Chemistry, Organic.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3445171
ISBN:	9781124541570

Engineering nanoparticles surface for biosensing: "Chemical noses" to detect and identify proteins, bacteria and cancerous cells.
Miranda-Sanchez, Oscar Ramon.

Engineering nanoparticles surface for biosensing: "Chemical noses" to detect and identify proteins, bacteria and cancerous cells. - 310 p.

Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: .

Thesis (Ph.D.)--University of Massachusetts Amherst, 2011.

Rapid and sensitive detection of biomolecules is an important issue in nanomedicine. Many disorders are manifested by changes in protein levels of serum and other biofluids. Rapid and effective differentiation between normal and cancerous cells is an important challenge for the diagnosis and treatment of tumor. Likewise, rapid and effective identification of pathogens is a key target in both biomedical and environmental monitoring. Most biological recognition processes occur via specific interactions. Gold nanoparticles (AuNP s) feature sizes commensurate with biomacromolecules, coupled with useful physical and optical properties. A key issue in the use of nanomaterials is controlling the interfacial interactions of these complex systems. Modulation of these physicochemical properties can be readily achieved by engineering nanoparticles surface. Inspired by the idea of mimicking nature, a convenient, precise and rapid method for sensing proteins, cancerous cells and bacteria has been developed by overtaking the superb performance of biological olfactory systems in odor detection, identification, tracking, and location. On the fundamental side, an array-based/'chemical nose' sensor composed of cationic functionalized AuNPs as receptors and anionic fluorescent conjugated polymers or green fluorescent proteins or enzyme/substrates as transducers that can properly detect and identify proteins, bacteria, and cancerous cells has been successfully fabricated.

ISBN: 9781124541570Subjects--Topical Terms:

193634
Chemistry, Organic.

Engineering nanoparticles surface for biosensing: "Chemical noses" to detect and identify proteins, bacteria and cancerous cells.
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500 $a Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: .
500 $a Adviser: Vincent M. Rotello.
502 $a Thesis (Ph.D.)--University of Massachusetts Amherst, 2011.
520 $a Rapid and sensitive detection of biomolecules is an important issue in nanomedicine. Many disorders are manifested by changes in protein levels of serum and other biofluids. Rapid and effective differentiation between normal and cancerous cells is an important challenge for the diagnosis and treatment of tumor. Likewise, rapid and effective identification of pathogens is a key target in both biomedical and environmental monitoring. Most biological recognition processes occur via specific interactions. Gold nanoparticles (AuNP s) feature sizes commensurate with biomacromolecules, coupled with useful physical and optical properties. A key issue in the use of nanomaterials is controlling the interfacial interactions of these complex systems. Modulation of these physicochemical properties can be readily achieved by engineering nanoparticles surface. Inspired by the idea of mimicking nature, a convenient, precise and rapid method for sensing proteins, cancerous cells and bacteria has been developed by overtaking the superb performance of biological olfactory systems in odor detection, identification, tracking, and location. On the fundamental side, an array-based/'chemical nose' sensor composed of cationic functionalized AuNPs as receptors and anionic fluorescent conjugated polymers or green fluorescent proteins or enzyme/substrates as transducers that can properly detect and identify proteins, bacteria, and cancerous cells has been successfully fabricated.
590 $a School code: 0118.
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650 4 $a Nanotechnology. $3 193873
650 4 $a Biophysics, Medical. $3 227040
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790 1 0 $a Rotello, Vincent M., $e advisor
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790 1 0 $a Voigtman, Edward G. $e committee member
790 1 0 $a Emrick, Todd S. $e committee member
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