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Negative regulation of regulatory T ...

Centuori, Sara.

Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.
Author:	Centuori, Sara.
Description:	90 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
Notes:	Advisers: Nicolas Larmonier; Emmanuel Katsanis.
Contained By:	Dissertation Abstracts International72-07B.
Subject:	Health Sciences, Immunology.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3452966
ISBN:	9781124608075

Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.
Centuori, Sara.

Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer. - 90 p.

Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .

Thesis (Ph.D.)--The University of Arizona, 2011.

Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play an essential role in the immunosuppressive networks that contribute to tumor immune evasion. The mechanisms by which tumors promote the expansion and/or function of these suppressive cells and the cross-regulation between MDSC and Treg remain incompletely defined. The current work evaluates the influence of MDSC, expanded in two mouse cancer models, on immunosuppressive Treg. We demonstrate that tumor-induced MDSC endowed with the potential of suppressing conventional T lymphocytes surprisingly impair TGF-beta1-mediated generation of induced Treg (iTreg) from naive CD4+ T lymphocytes. Suppression of iTreg generation by MDSC occurs early in the differentiation process, and is cell contact dependent. This inhibition of FoxP3-expressing T lymphocyte differentiation by MDSC does not depend on arginase 1, cystine/cysteine depletion, iNOS/NO, or PD-1/PD-L1 signaling. These findings therefore indicate that MDSC from tumor-bearing hosts have the heretofore unreported ability to restrict some immunosuppressive Treg subpopulations.

ISBN: 9781124608075Subjects--Topical Terms:

226966
Health Sciences, Immunology.

Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.
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245 1 0 $a Negative regulation of regulatory T cells by myeloid-derived suppressor cells in cancer.
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502 $a Thesis (Ph.D.)--The University of Arizona, 2011.
520 $a Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play an essential role in the immunosuppressive networks that contribute to tumor immune evasion. The mechanisms by which tumors promote the expansion and/or function of these suppressive cells and the cross-regulation between MDSC and Treg remain incompletely defined. The current work evaluates the influence of MDSC, expanded in two mouse cancer models, on immunosuppressive Treg. We demonstrate that tumor-induced MDSC endowed with the potential of suppressing conventional T lymphocytes surprisingly impair TGF-beta1-mediated generation of induced Treg (iTreg) from naive CD4+ T lymphocytes. Suppression of iTreg generation by MDSC occurs early in the differentiation process, and is cell contact dependent. This inhibition of FoxP3-expressing T lymphocyte differentiation by MDSC does not depend on arginase 1, cystine/cysteine depletion, iNOS/NO, or PD-1/PD-L1 signaling. These findings therefore indicate that MDSC from tumor-bearing hosts have the heretofore unreported ability to restrict some immunosuppressive Treg subpopulations.
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