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The role of Programmed Death-1 (PD-1...

Parkman, Julia Catherine.

The role of Programmed Death-1 (PD-1) expression in the negative selection of T lymphocytes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The role of Programmed Death-1 (PD-1) expression in the negative selection of T lymphocytes.
Author:	Parkman, Julia Catherine.
Description:	205 p.
Notes:	Source: Masters Abstracts International, Volume: 49-04, page: 2430.
Contained By:	Masters Abstracts International49-04.
Subject:	Health Sciences, Immunology.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR70888
ISBN:	9780494708880

The role of Programmed Death-1 (PD-1) expression in the negative selection of T lymphocytes.
Parkman, Julia Catherine.

The role of Programmed Death-1 (PD-1) expression in the negative selection of T lymphocytes. - 205 p.

Source: Masters Abstracts International, Volume: 49-04, page: 2430.

Thesis (M.Sc.)--University of Alberta (Canada), 2011.

The immune system must be able to mount a response against pathogens and transformed cells while remaining tolerant to healthy host tissue. A key process for ensuring this self-tolerance is the negative selection of self-reactive thymocytes. Expression of Programmed Death-1 (PD-1), a co-inhibitory member of the CD28 family associated with dampened peripheral immune responses, was found to be upregulated in 20-40% of thymocytes undergoing negative selection in the HYcd4 model of thymic development. Although analysis of gene and protein expression directly ex vivo indicates that PD-1 - and PD-1+ thymocytes are equally apoptotic, PD-1 + thymocytes appear to be protected from apoptosis in an in vitro stimulation assay. Analysis of HYcd4PD-1 -/- mice indicates that thymocytes receive a higher intensity signal in the absence of PD-1. Future work utilizing HYcd4PD-1 -/- mice will increase our understanding of the role of PD-1 in thymic negative selection.

ISBN: 9780494708880Subjects--Topical Terms:

226966
Health Sciences, Immunology.

The role of Programmed Death-1 (PD-1) expression in the negative selection of T lymphocytes.
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245 1 4 $a The role of Programmed Death-1 (PD-1) expression in the negative selection of T lymphocytes.
300 $a 205 p.
500 $a Source: Masters Abstracts International, Volume: 49-04, page: 2430.
502 $a Thesis (M.Sc.)--University of Alberta (Canada), 2011.
520 $a The immune system must be able to mount a response against pathogens and transformed cells while remaining tolerant to healthy host tissue. A key process for ensuring this self-tolerance is the negative selection of self-reactive thymocytes. Expression of Programmed Death-1 (PD-1), a co-inhibitory member of the CD28 family associated with dampened peripheral immune responses, was found to be upregulated in 20-40% of thymocytes undergoing negative selection in the HYcd4 model of thymic development. Although analysis of gene and protein expression directly ex vivo indicates that PD-1 - and PD-1+ thymocytes are equally apoptotic, PD-1 + thymocytes appear to be protected from apoptosis in an in vitro stimulation assay. Analysis of HYcd4PD-1 -/- mice indicates that thymocytes receive a higher intensity signal in the absence of PD-1. Future work utilizing HYcd4PD-1 -/- mice will increase our understanding of the role of PD-1 in thymic negative selection.
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