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Protein-protein complexesanalysis, m...

World Scientific (Firm)

Protein-protein complexesanalysis, modeling and drug design /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Protein-protein complexesedited by Martin Zacharias.
Reminder of title:	analysis, modeling and drug design /
other author:	Zacharias, Martin.
Published:	London :Imperial College Press ;c2010.
Description:	ix, 390 p. :ill. (some col.)
Subject:	Protein-protein interactions.
Online resource:	http://www.worldscientific.com/worldscibooks/10.1142/P618#t=toc
ISBN:	9781848163409 (electronic bk.)

Protein-protein complexesanalysis, modeling and drug design /
Protein-protein complexesanalysis, modeling and drug design /[electronic resource] :edited by Martin Zacharias. - London :Imperial College Press ;c2010. - ix, 390 p. :ill. (some col.)

Includes bibliographical references and index.

Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics? The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein?protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.

Electronic reproduction.
Singapore :
World Scientific Publishing Co.,
2010.

System requirements: Adobe Acrobat Reader.

ISBN: 9781848163409 (electronic bk.)Subjects--Topical Terms:

265915
Protein-protein interactions.

LC Class. No.: QP551.5

Dewey Class. No.: 572.633

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300 $a ix, 390 p. : $b ill. (some col.)
504 $a Includes bibliographical references and index.
520 $a Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics? The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein?protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.
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