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The quantal theory of immunitythe mo...

Smith, Kendall A.

The quantal theory of immunitythe molecular basis of autoimmunity and leukemia /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The quantal theory of immunityKendall A. Smith.
Reminder of title:	the molecular basis of autoimmunity and leukemia /
Author:	Smith, Kendall A.
Published:	Singapore ;World Scientific Pub. Co.,c2010.
Description:	xi, 235 p. :ill. (some col.)
Subject:	Immune response.
Online resource:	http://www.worldscientific.com/worldscibooks/10.1142/7269#t=toc
ISBN:	9789814271769 (electronic bk.)

The quantal theory of immunitythe molecular basis of autoimmunity and leukemia /
Smith, Kendall A.

The quantal theory of immunitythe molecular basis of autoimmunity and leukemia /[electronic resource] :Kendall A. Smith. - Singapore ;World Scientific Pub. Co.,c2010. - xi, 235 p. :ill. (some col.)

Includes bibliographical references and index.

This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to "count" the number of foreign antigenic molecular "hits", and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented.

Electronic reproduction.
Singapore :
World Scientific Publishing Co.,
2010.

System requirements: Adobe Acrobat Reader.

ISBN: 9789814271769 (electronic bk.)Subjects--Topical Terms:

216499
Immune response.

LC Class. No.: QR186

Dewey Class. No.: 616.97/8

The quantal theory of immunitythe molecular basis of autoimmunity and leukemia /
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245 1 4 $a The quantal theory of immunity $h [electronic resource] : $b the molecular basis of autoimmunity and leukemia / $c Kendall A. Smith.
260 $a Singapore ; $a Hackensack, N.J. : $b World Scientific Pub. Co., $c c2010.
300 $a xi, 235 p. : $b ill. (some col.)
504 $a Includes bibliographical references and index.
520 $a This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to "count" the number of foreign antigenic molecular "hits", and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented.
533 $a Electronic reproduction. $b Singapore : $c World Scientific Publishing Co., $d 2010. $n System requirements: Adobe Acrobat Reader. $n Mode of access: World Wide Web. $n Available to subscribing institutions.
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856 4 0 $u http://www.worldscientific.com/worldscibooks/10.1142/7269#t=toc