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尿液中生物指標分子(香草扁桃酸和退黑激素)拓印聚乙烯乙烯醇電極之製備並應...

國立高雄大學化學工程及材料工程學系碩士班

尿液中生物指標分子(香草扁桃酸和退黑激素)拓印聚乙烯乙烯醇電極之製備並應用於差式脈波伏安法電化學感測系統 = Biomarkes (vanillylmandelic acid and melatonin) in urine imprinted poly(ethylene-co-vinyl alcohol) coated electrode for differential pulse voltammetric sensing system

Record Type:	Language materials, printed : monographic
Paralel Title:	Biomarkes (vanillylmandelic acid and melatonin) in urine imprinted poly(ethylene-co-vinyl alcohol) coated electrode for differential pulse voltammetric sensing system
Author:	陳奕吏,
Secondary Intellectual Responsibility:	國立高雄大學
Place of Publication:	[高雄市]
Published:	撰者;
Year of Publication:	2012[民101]
Description:	159面彩圖，表格 : 30公分;
Subject:	微流體感測器系統
Subject:	molecular imprinting
Online resource:	http://handle.ncl.edu.tw/11296/ndltd/41800392518786323449
Notes:	106年10月31日公開
Notes:	參考書目：面139-145
Summary:	香草扁桃酸和退黑激素在人體尿液中被發現可能為高血壓疾病和乳腺癌的重要指標分子。在本研究中，將藉由聚乙烯-乙烯醇為拓印分子的智慧材料，以分子拓印技術，製備香草扁桃酸和退黑激素分子拓印聚乙烯乙烯醇薄膜電極，在生物檢體中具有專一的辨識性的效果，分別對於乙烯莫爾比例32和44的聚乙烯乙烯醇有較好的拓印效率。並將此作為電極感測元件進行電化學測量，應用於生物感測器之設計，再將樣品進樣、流體傳送、感測與環境監控等功能整合，將提供生物檢測上一個可攜帶式、便利且具快速檢測的電化學感測系統。為了使量測方法的靈敏度提高與更微小化的感測裝置，將藉助強制對流的方式，在微流體系統中進行尿液檢體檢測。 Vanillylmandelic acid and melatonin was identified as a differential metabolite that was highly increased during hypertensive disorders and breast cancer progression to metastasis and can be detected non-invasively in urine. In this work, the molecularly imprinting technolology of vanillylmandelic acid and melatonin molecules which were then imprinted into poly (ethylene-co-vinyl alcohol) via solvent evaporation, the highest imprinting effectiveness for vanillylmandelic acid and melatonin was obtained with 32mol% and 44mole % of ethylene, respectively. Target molecules on membrane are then removal, and the membrane is used as the sensing element for electrochemical urinalysis. Voltammetry measurements of samples in this miniaturized sensor were performed by microfluid system as well as real urine samples.

尿液中生物指標分子(香草扁桃酸和退黑激素)拓印聚乙烯乙烯醇電極之製備並應用於差式脈波伏安法電化學感測系統 = Biomarkes (vanillylmandelic acid and melatonin) in urine imprinted poly(ethylene-co-vinyl alcohol) coated electrode for differential pulse voltammetric sensing system
陳, 奕吏

尿液中生物指標分子(香草扁桃酸和退黑激素)拓印聚乙烯乙烯醇電極之製備並應用於差式脈波伏安法電化學感測系統 = Biomarkes (vanillylmandelic acid and melatonin) in urine imprinted poly(ethylene-co-vinyl alcohol) coated electrode for differential pulse voltammetric sensing system / 陳奕吏撰 - [高雄市] : 撰者, 2012[民101]. - 159面 ; 彩圖，表格 ; 30公分.
106年10月31日公開參考書目：面139-145.
微流體感測器系統molecular imprinting

尿液中生物指標分子(香草扁桃酸和退黑激素)拓印聚乙烯乙烯醇電極之製備並應用於差式脈波伏安法電化學感測系統 = Biomarkes (vanillylmandelic acid and melatonin) in urine imprinted poly(ethylene-co-vinyl alcohol) coated electrode for differential pulse voltammetric sensing system
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