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Diversity-oriented synthesisbasics a...

Trabocchi, Andrea.

Diversity-oriented synthesisbasics and applications in organic synthesis, drug discovery, and chemical biology /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Diversity-oriented synthesisedited by Andrea Trabocchi, Sesto Fiorentino.
Reminder of title:	basics and applications in organic synthesis, drug discovery, and chemical biology /
other author:	Trabocchi, Andrea.
Published:	Hoboken, New Jersey :Wiley,2013.
Description:	1 online resource (xxxiii, 645 p.) :ill.
Subject:	Organic compoundsSynthesis.
Online resource:	http://onlinelibrary.wiley.com/book/10.1002/9781118618110
ISBN:	9781118618110 (electronic bk.)

Diversity-oriented synthesisbasics and applications in organic synthesis, drug discovery, and chemical biology /
Diversity-oriented synthesisbasics and applications in organic synthesis, drug discovery, and chemical biology /[electronic resource] :edited by Andrea Trabocchi, Sesto Fiorentino. - Hoboken, New Jersey :Wiley,2013. - 1 online resource (xxxiii, 645 p.) :ill.

Includes bibliographical references and index.

Machine generated contents note: Foreword Stuart L. Schreiber Preface List of Contributors Abbreviations 1 The Basics of Diversity-Oriented Synthesis Kieron M.G. O'Connell, Warren R.J.D. Galloway and David R. Spring 1.1 Introduction 1.2 What is Diversity-Oriented Synthesis? 1.3 Small Molecules and Biology 1.4 Comparing DOS, TOS and Combinatorial Chemistry (Focused Library Synthesis) 1.5 Molecular Diversity 1.6 Molecular Diversity and Chemical Space 1.7 Synthetic Strategies for Creating Molecular Diversity 1.8 Reagent-Based Approaches to Diversity Generation 1.9 A Substrate-Based Approach to Skeletal Diversity Generation 1.10 Other Build/Couple/Pair Examples 1.11 Concluding Remarks 1.12 References Part I Chemical Methodology in Diversity-Oriented Synthesis 2 Strategies Applications of Multicomponent Reactions (MCRs) to Diversity-Oriented Synthesis John M. Knapp, Mark J. Kurth, Jared T. Shaw and Ashkaan Younai 2.1 Introduction 2.2 MCR Products for HTS 2.3 MCRs as Starting Points for DOS 2.4 Conclusion 2.5 References 3 Cycloaddition Reactions in Diversity-Oriented Synthesis Giovanni Muncipinto 3.1 Introduction 3.2 [4+2] Cycloaddition Reactions 3.3 Diels-Alder Reaction 3.4 Inverse Electron Demand Diels-Alder Reaction 3.5 1,3-dipolar Cycloaddition Reactions 3.6 Miscellaneous Cycloadditions 3.7 Conclusion 3.8 References 4 Phosphine Organocatalysis as the Platform for Diversity-Oriented Synthesis Ohyun Kwon and Zhiming Wang 4.1 Introduction 4.2 DOS using Phosphine Organocatalysis 4.2.1 Phosphine Organocatalysis of Allenes with Imines 4.3 Skeletal Diversity Based on a Phosphine Catalysis/Combinatorial Scaffolding Strategy 4.4 A DOS Library Based on Phosphine Organocatalysis: Biological Screening, Analogue Synthesis, and Structure-Activity Relationship Analysis 4.5 Conclusions 4.6 References 5 Domino Reactions in Library Synthesis Matthew G. LaPorte, John R. Goodell, Sammi Tsegay and Peter Wipf 5.1 Introduction 5.2 Pericyclic Domino Reactions 5.3 Anionic Domino Reactions

"This book overviews diversity-oriented synthesis (DOS), one of the leading and dynamic topics in organic chemistry and drug discovery"--

ISBN: 9781118618110 (electronic bk.)

LCCN: 2013008031Subjects--Topical Terms:

193643
Organic compounds
--Synthesis.

LC Class. No.: QD262

Dewey Class. No.: 547/.2

Diversity-oriented synthesisbasics and applications in organic synthesis, drug discovery, and chemical biology /
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020 $z 1118618076
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245 0 0 $a Diversity-oriented synthesis $h [electronic resource] : $b basics and applications in organic synthesis, drug discovery, and chemical biology / $c edited by Andrea Trabocchi, Sesto Fiorentino.
260 $a Hoboken, New Jersey : $b Wiley, $c 2013.
300 $a 1 online resource (xxxiii, 645 p.) : $b ill.
504 $a Includes bibliographical references and index.
505 8 $a Machine generated contents note: Foreword Stuart L. Schreiber Preface List of Contributors Abbreviations 1 The Basics of Diversity-Oriented Synthesis Kieron M.G. O'Connell, Warren R.J.D. Galloway and David R. Spring 1.1 Introduction 1.2 What is Diversity-Oriented Synthesis? 1.3 Small Molecules and Biology 1.4 Comparing DOS, TOS and Combinatorial Chemistry (Focused Library Synthesis) 1.5 Molecular Diversity 1.6 Molecular Diversity and Chemical Space 1.7 Synthetic Strategies for Creating Molecular Diversity 1.8 Reagent-Based Approaches to Diversity Generation 1.9 A Substrate-Based Approach to Skeletal Diversity Generation 1.10 Other Build/Couple/Pair Examples 1.11 Concluding Remarks 1.12 References Part I Chemical Methodology in Diversity-Oriented Synthesis 2 Strategies Applications of Multicomponent Reactions (MCRs) to Diversity-Oriented Synthesis John M. Knapp, Mark J. Kurth, Jared T. Shaw and Ashkaan Younai 2.1 Introduction 2.2 MCR Products for HTS 2.3 MCRs as Starting Points for DOS 2.4 Conclusion 2.5 References 3 Cycloaddition Reactions in Diversity-Oriented Synthesis Giovanni Muncipinto 3.1 Introduction 3.2 [4+2] Cycloaddition Reactions 3.3 Diels-Alder Reaction 3.4 Inverse Electron Demand Diels-Alder Reaction 3.5 1,3-dipolar Cycloaddition Reactions 3.6 Miscellaneous Cycloadditions 3.7 Conclusion 3.8 References 4 Phosphine Organocatalysis as the Platform for Diversity-Oriented Synthesis Ohyun Kwon and Zhiming Wang 4.1 Introduction 4.2 DOS using Phosphine Organocatalysis 4.2.1 Phosphine Organocatalysis of Allenes with Imines 4.3 Skeletal Diversity Based on a Phosphine Catalysis/Combinatorial Scaffolding Strategy 4.4 A DOS Library Based on Phosphine Organocatalysis: Biological Screening, Analogue Synthesis, and Structure-Activity Relationship Analysis 4.5 Conclusions 4.6 References 5 Domino Reactions in Library Synthesis Matthew G. LaPorte, John R. Goodell, Sammi Tsegay and Peter Wipf 5.1 Introduction 5.2 Pericyclic Domino Reactions 5.3 Anionic Domino Reactions
520 $a "This book overviews diversity-oriented synthesis (DOS), one of the leading and dynamic topics in organic chemistry and drug discovery"-- $c Provided by publisher.
588 $a Description based on online resource; title from PDF title page (Wiley, viewed July 10, 2013)
650 0 $a Organic compounds $x Synthesis. $3 193643
650 0 $a Drug development. $3 190608
650 0 $a Biosynthesis. $3 205687
700 1 $a Trabocchi, Andrea. $3 699325
856 4 0 $u http://onlinelibrary.wiley.com/book/10.1002/9781118618110