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Molecular Genetic Analysis of Networ...

Northwestern University.

Molecular Genetic Analysis of Network Properties Controlling Drosophila Circadian Behavior.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular Genetic Analysis of Network Properties Controlling Drosophila Circadian Behavior.
Author:	Seluzicki, Adam.
Description:	212 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
Notes:	Advisers: Ravi Allada; Richard Carthew.
Contained By:	Dissertation Abstracts International75-07B(E).
Subject:	Genetics.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3615511
ISBN:	9781303815294

Molecular Genetic Analysis of Network Properties Controlling Drosophila Circadian Behavior.
Seluzicki, Adam.

Molecular Genetic Analysis of Network Properties Controlling Drosophila Circadian Behavior. - 212 p.

Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.

Thesis (Ph.D.)--Northwestern University, 2014.

This item must not be sold to any third party vendors.

Circadian clock systems endow organisms with the ability to tune physiology and behavior to oscillating environmental conditions. Independently evolved systems share some basic structure, consisting of biochemical negative feedback loops within each cell that are primarily set by light and temperature input from the environment. In animals these oscillators are embedded in another layer of regulation; they are linked by intercellular signaling pathways into networks that provide resistance to noise and perturbation. Differentially regulating regions of the network provides flexibility in daily and seasonal organization of behavior. The Drosophila circadian pacemaker network consists of approximately 150 neurons, each containing a molecular clock. The importance of intercellular communication in this and other model systems has been shown to be critical for maintaining the integrity of the individual oscillators as well as the temporal organization of behavior. Additionally, modulation of network properties, including membrane excitability and firing rate, is known to be required for normal behavior patterns.

ISBN: 9781303815294Subjects--Topical Terms:

189015
Genetics.

Molecular Genetic Analysis of Network Properties Controlling Drosophila Circadian Behavior.
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245 1 0 $a Molecular Genetic Analysis of Network Properties Controlling Drosophila Circadian Behavior.
300 $a 212 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
500 $a Advisers: Ravi Allada; Richard Carthew.
502 $a Thesis (Ph.D.)--Northwestern University, 2014.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Circadian clock systems endow organisms with the ability to tune physiology and behavior to oscillating environmental conditions. Independently evolved systems share some basic structure, consisting of biochemical negative feedback loops within each cell that are primarily set by light and temperature input from the environment. In animals these oscillators are embedded in another layer of regulation; they are linked by intercellular signaling pathways into networks that provide resistance to noise and perturbation. Differentially regulating regions of the network provides flexibility in daily and seasonal organization of behavior. The Drosophila circadian pacemaker network consists of approximately 150 neurons, each containing a molecular clock. The importance of intercellular communication in this and other model systems has been shown to be critical for maintaining the integrity of the individual oscillators as well as the temporal organization of behavior. Additionally, modulation of network properties, including membrane excitability and firing rate, is known to be required for normal behavior patterns.
520 $a The work described herein examines intercellular signaling, light-sensing, and clock-independent properties of the Drosophila pacemaker network in the control of diurnal and rhythmic behaviors. In Chapter 2, I characterize the mechanisms by which neuropeptide signaling controls oscillator synchrony in the network. I demonstrate that the key neuropeptide, PIGMENT DISPERSING FACTOR (PDF), acts via PROTEIN KINASE A (PKA) to regulate the core clock protein, TIMELESS (TIM), thereby controlling the molecular clock in downstream neurons. Chapter 3 is a genetic and behavioral characterization of the functions of unidentified signaling pathways operating in parallel with PDF to regulate light inputs to the core clock. I describe a model in which at least two novel intercellular signals are important for the control of multiple aspects of rhythmic behavior and characterize potential interactions with known signaling components. Chapter 4 describes rhythmic behaviors present in the absence or reduction of canonical molecular clock function. I characterize behaviors that are both light suppressible and promoted by modulating membrane excitability in the pacemaker network. I present molecular rhythms that persist in constant conditions in the absence of the core circadian transcription factor, PERIOD (PER). I also examine the possible role of clock-independent oscillators in regulating behavior.
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773 0 $t Dissertation Abstracts International $g 75-07B(E).
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