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Molecular basis for uranium toxicity.

Burbank, Katherine Ann.

Molecular basis for uranium toxicity.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular basis for uranium toxicity.
Author:	Burbank, Katherine Ann.
Description:	254 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
Notes:	Advisers: Brent M. Peyton; Robert A. Walker.
Contained By:	Dissertation Abstracts International75-11B(E).
Subject:	Biochemistry.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3630532
ISBN:	9781321085167

Molecular basis for uranium toxicity.
Burbank, Katherine Ann.

Molecular basis for uranium toxicity. - 254 p.

Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.

Thesis (Ph.D.)--Montana State University, 2014.

This item must not be sold to any third party vendors.

Environmental and health problems associated with uranium extend well beyond its radioactive properties. Hexavelent uranium is a common environmental contaminant that reacts with water to form the dioxo-uranium cation, UO22+. Environmental uranium contamination is the result of a number of activities including uranium mining, production and use of depleted uranium for military purposes, storage and disposal of nuclear weaponry, and fuel for nuclear power plants. Despite the potential importance of the interaction of UO22+ with biologically relevant molecules, only limited molecular insight is available. In a recent publication, the presence of UO22+ in submicromolar concentrations was shown to affect ethanol metabolism in Pseudomonas spp. by displacing the Ca2+ of the pyrroloquinoline quinone (PQQ) cofactor. Accordingly, the interaction of UO2 2+ with PQQ is used here as a starting point to carry out both an in vitro and in silico analysis of UO2 2+ and its interactions with biologically relevant cofactors and metabolites. This work represents a proposed molecular mechanism of uranium toxicity in bacteria, and has relevance for uranium toxicity in many living systems. The structural insights from modeling allow us to expand the scope of potential uranium toxicity to other systems by considering the favorable coordination mode to pyridine nitrogen adjacent to carboxylic and/or carbonyl groups. Consequently, the recent discovery of uranium toxicity at submicromolar levels in bacteria provides relevance to serious environmental and public health issues in the light of current EPA regulation of 0.13 muM uranium limit in drinking water.

ISBN: 9781321085167Subjects--Topical Terms:

188609
Biochemistry.

Molecular basis for uranium toxicity.
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100 1 $a Burbank, Katherine Ann. $3 708703
245 1 0 $a Molecular basis for uranium toxicity.
300 $a 254 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
500 $a Advisers: Brent M. Peyton; Robert A. Walker.
502 $a Thesis (Ph.D.)--Montana State University, 2014.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Environmental and health problems associated with uranium extend well beyond its radioactive properties. Hexavelent uranium is a common environmental contaminant that reacts with water to form the dioxo-uranium cation, UO22+. Environmental uranium contamination is the result of a number of activities including uranium mining, production and use of depleted uranium for military purposes, storage and disposal of nuclear weaponry, and fuel for nuclear power plants. Despite the potential importance of the interaction of UO22+ with biologically relevant molecules, only limited molecular insight is available. In a recent publication, the presence of UO22+ in submicromolar concentrations was shown to affect ethanol metabolism in Pseudomonas spp. by displacing the Ca2+ of the pyrroloquinoline quinone (PQQ) cofactor. Accordingly, the interaction of UO2 2+ with PQQ is used here as a starting point to carry out both an in vitro and in silico analysis of UO2 2+ and its interactions with biologically relevant cofactors and metabolites. This work represents a proposed molecular mechanism of uranium toxicity in bacteria, and has relevance for uranium toxicity in many living systems. The structural insights from modeling allow us to expand the scope of potential uranium toxicity to other systems by considering the favorable coordination mode to pyridine nitrogen adjacent to carboxylic and/or carbonyl groups. Consequently, the recent discovery of uranium toxicity at submicromolar levels in bacteria provides relevance to serious environmental and public health issues in the light of current EPA regulation of 0.13 muM uranium limit in drinking water.
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