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Skeletal Muscle Sympathetic Vasocons...
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Jendzjowsky, Nicholas G.
Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training.
Record Type:
Electronic resources : Monograph/item
Title/Author:
Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training.
Author:
Jendzjowsky, Nicholas G.
Description:
160 p.
Notes:
Source: Dissertation Abstracts International, Volume: 75-06(E), Section: A.
Contained By:
Dissertation Abstracts International75-06A(E).
Subject:
Recreation.
Online resource:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NS27580
ISBN:
9780499275806
Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training.
Jendzjowsky, Nicholas G.
Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training.
- 160 p.
Source: Dissertation Abstracts International, Volume: 75-06(E), Section: A.
Thesis (Ph.D.)--University of Alberta (Canada), 2013.
This item must not be sold to any third party vendors.
The purpose of this thesis was to investigate the effects of short-term endurance exercise training (ET) on sympathetic vasoconstriction in resting and contracting skeletal muscle. To achieve these aims, rats were exercise trained on a motorized treadmill and an anesthetised whole animal in situ vascular preparation was used to investigate the effects of ET on sympathetic vascular control in resting and contracting skeletal muscle.
ISBN: 9780499275806Subjects--Topical Terms:
201907
Recreation.
Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training.
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Skeletal Muscle Sympathetic Vasoconstrictor Control Following Short-Term Mild- and Heavy-Intensity Exercise Training.
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160 p.
500
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Source: Dissertation Abstracts International, Volume: 75-06(E), Section: A.
502
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Thesis (Ph.D.)--University of Alberta (Canada), 2013.
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This item must not be sold to any third party vendors.
520
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The purpose of this thesis was to investigate the effects of short-term endurance exercise training (ET) on sympathetic vasoconstriction in resting and contracting skeletal muscle. To achieve these aims, rats were exercise trained on a motorized treadmill and an anesthetised whole animal in situ vascular preparation was used to investigate the effects of ET on sympathetic vascular control in resting and contracting skeletal muscle.
520
$a
Exercise training augmented resting sympathetic vasoconstrictor responsiveness in a training intensity-dependent manner. Concurrently, endothelium-dependent vasodilation was augmented in a training intensity-dependent manner and significantly correlated to the magnitude of sympathetic vasoconstrictor responsiveness.
520
$a
During acute exercise sympathetic outflow is increased however the vascular response to sympathetic stimulation is diminished and aids in the regulation of skeletal muscle blood flow; a physiologic phenomenon termed functional sympatholysis. The inhibition of sympathetic vasoconstriction during muscular contraction was augmented in a manner influenced by the intensity of ET through a nitric oxide-dependent mechanism.
520
$a
Given the increased resting sympathetic vasoconstrictor responsiveness and enhanced sympatholysis following training, it was hypothesized that ET may mediate these effects, in part, by an altered contribution of post-synaptic alpha 2- adrenergic receptors to the regulation of sympathetic vasoconstriction. Exercise training significantly augmented the contribution of alpha 2-adrenergic receptor to basal sympathetic vasoconstriction. During contraction the alpha2-adrenergic receptor was relatively resistant to inhibition. The ET induced increase in sympatholysis was mediated, in part, by the inhibition of the alpha1-adrenergic receptor through a nitric oxide-dependent mechanism.
520
$a
Collectively, these results highlight the integrated nature of ET mediated adaptations to sympathetic regulation of skeletal muscle vascular conductance and the plasticity of sympathetic regulation of skeletal muscle vascular conductance.
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School code: 0351.
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Recreation.
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201907
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University of Alberta (Canada).
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Physical Education and Recreation.
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2013
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English
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NS27580
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