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Behcet's diseasefrom genetics to the...

Ishigatsubo, Yoshiaki.

Behcet's diseasefrom genetics to therapies /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Behcet's diseaseedited by Yoshiaki Ishigatsubo.
Reminder of title:	from genetics to therapies /
other author:	Ishigatsubo, Yoshiaki.
Published:	Tokyo :Springer Japan :2015.
Description:	ix, 176 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Behcet's diseaseGenetic aspects.
Online resource:	http://dx.doi.org/10.1007/978-4-431-54487-6
ISBN:	9784431544876 (electronic bk.)

Behcet's diseasefrom genetics to therapies /
Behcet's diseasefrom genetics to therapies /[electronic resource] :edited by Yoshiaki Ishigatsubo. - Tokyo :Springer Japan :2015. - ix, 176 p. :ill. (some col.), digital ;24 cm.

1. Overview -- 2. The Immunopathology of Behcet’s Disease -- 3. Genetics -- 4. Ocular Involvement -- 5. Vascular Involvement of Behcet's Disease -- 6. Neurological Involvement -- 7. Gastrointestinal Involvement -- 8. Mucocutaneous Manifestations -- 9. Perspective .

This book, besides reviewing basic and clinical aspects of Behcet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behçet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behcet's disease. Behcet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.

ISBN: 9784431544876 (electronic bk.)

Standard No.: 10.1007/978-4-431-54487-6doiSubjects--Topical Terms:

713211
Behcet's disease
--Genetic aspects.

LC Class. No.: RC122.B4

Dewey Class. No.: 616.9

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505 0 $a 1. Overview -- 2. The Immunopathology of Behcet’s Disease -- 3. Genetics -- 4. Ocular Involvement -- 5. Vascular Involvement of Behcet's Disease -- 6. Neurological Involvement -- 7. Gastrointestinal Involvement -- 8. Mucocutaneous Manifestations -- 9. Perspective .
520 $a This book, besides reviewing basic and clinical aspects of Behcet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behçet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behcet's disease. Behcet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.
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