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Targeted genome editing using site-specific nucleasesZFNs, TALENs, and the CRISPR/Cas9 system /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Targeted genome editing using site-specific nucleasesedited by Takashi Yamamoto.
Reminder of title:	ZFNs, TALENs, and the CRISPR/Cas9 system /
other author:	Yamamoto, Takashi.
Published:	Tokyo :Springer Japan :2015.
Description:	viii, 205 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Gene targeting.
Online resource:	http://dx.doi.org/10.1007/978-4-431-55227-7
ISBN:	9784431552277 (electronic bk.)

Targeted genome editing using site-specific nucleasesZFNs, TALENs, and the CRISPR/Cas9 system /
Targeted genome editing using site-specific nucleasesZFNs, TALENs, and the CRISPR/Cas9 system /[electronic resource] :edited by Takashi Yamamoto. - Tokyo :Springer Japan :2015. - viii, 205 p. :ill. (some col.), digital ;24 cm.

This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

ISBN: 9784431552277 (electronic bk.)

Standard No.: 10.1007/978-4-431-55227-7doiSubjects--Topical Terms:

225570
Gene targeting.

LC Class. No.: QH442.3

Dewey Class. No.: 660.65

Targeted genome editing using site-specific nucleasesZFNs, TALENs, and the CRISPR/Cas9 system /
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520 $a This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.
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