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Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cellsmathematical modeling and experimental observations /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cellsby Iman Tavassoly.
Reminder of title:	mathematical modeling and experimental observations /
Author:	Tavassoly, Iman.
Published:	Cham :Springer International Publishing :2015.
Description:	xxi, 79 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Cell determinationMathematical models.
Online resource:	http://dx.doi.org/10.1007/978-3-319-14962-2
ISBN:	9783319149622 (electronic bk.)

Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cellsmathematical modeling and experimental observations /
Tavassoly, Iman.

Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cellsmathematical modeling and experimental observations /[electronic resource] :by Iman Tavassoly. - Cham :Springer International Publishing :2015. - xxi, 79 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Mathematical Modeling of the Interplay of Autophagy and Apoptosis -- An Experimental Framework to Study the Dynamics of Autophagic Response -- Conclusions -- Source Code.

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

ISBN: 9783319149622 (electronic bk.)

Standard No.: 10.1007/978-3-319-14962-2doiSubjects--Topical Terms:

714028
Cell determination
--Mathematical models.

LC Class. No.: QL963.5

Dewey Class. No.: 571.8636

Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cellsmathematical modeling and experimental observations /
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