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Cytochrome P450structure, mechanism,...

Ortiz de Montellano, Paul R.

Cytochrome P450structure, mechanism, and biochemistry /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Cytochrome P450edited by Paul R. Ortiz de Montellano.
其他題名:	structure, mechanism, and biochemistry /
其他作者:	Ortiz de Montellano, Paul R.
出版者:	Cham :Springer International Publishing :2015.
面頁冊數:	x, 912 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Cytochrome P-450.
電子資源:	http://dx.doi.org/10.1007/978-3-319-12108-6
ISBN:	9783319121086 (electronic bk.)

Cytochrome P450structure, mechanism, and biochemistry /
Cytochrome P450structure, mechanism, and biochemistry /[electronic resource] :edited by Paul R. Ortiz de Montellano. - 4th ed. - Cham :Springer International Publishing :2015. - x, 912 p. :ill., digital ;24 cm.

Volume 1 -- 1 Structures of Cytochrome P450 Enzymes -- 2 Electron Transfer Partners of Cytochrome P450 -- 3 Activation of Molecular Oxygen in Cytochromes P450 -- 4 Substrate Oxidation by Cytochrome P450 Enzymes -- 5 Inhibition of Cytochrome P450 Enzymes -- 6 Microbial Cytochromes P450 -- 7 P450s in Plants, Insects and their Fungal Pathogens -- 8 P450 Biotechnology -- Volume 2 -- 9 Human Cytochrome P450 Enzymes -- 10 Nuclear Receptor-Mediated Regulation of Cytochrome P450 Genes -- 11 Hormonal Regulation of Liver Cytochrome P450 Enzymes -- 12 P450 Enzymes in Steroid Processing -- 13 P450 Enzymes in Lipid Oxidation.

This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.

ISBN: 9783319121086 (electronic bk.)

Standard No.: 10.1007/978-3-319-12108-6doiSubjects--Topical Terms:

202617
Cytochrome P-450.

LC Class. No.: QP671.C83

Dewey Class. No.: 572.59

Cytochrome P450structure, mechanism, and biochemistry /
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520 $a This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.
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