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The impact of food bioactives on healthin vitro and ex vivo models /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The impact of food bioactives on healthedited by Kitty Verhoeckx ... [et al.].
Reminder of title:	in vitro and ex vivo models /
other author:	Verhoeckx, Kitty.
Published:	Cham :Springer International Publishing :2015.
Description:	xvii, 338 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Gastrointestinal systemMicrobiology.
Online resource:	http://dx.doi.org/10.1007/978-3-319-16104-4
ISBN:	9783319161044 (electronic bk.)

The impact of food bioactives on healthin vitro and ex vivo models /
The impact of food bioactives on healthin vitro and ex vivo models /[electronic resource] :edited by Kitty Verhoeckx ... [et al.]. - Cham :Springer International Publishing :2015. - xvii, 338 p. :ill., digital ;24 cm.

Introduction -- Gastrointestinal digestion models, general introduction -- Static digestion models general introduction -- InfoGest consensus method -- Approaches to static digestion models -- Dynamic digestion models general introduction -- The TNO gastro-Intestinal Model (TIM) -- Dynamic Gastric Model (DGM) -- Human Gastric Simulator (Riddet model) -- The DIDGI System -- General introduction to cells, cell lines and cell culture -- Epithelial cell models; General introduction -- Caco-2 cell line -- HT29 cell line -- The IPEC-J2 cell line -- Co-cultivation of Caco-2 and HT-29MT -- Innate and adaptive immune cells; General introduction -- THP-1 and U937 cells -- Peripheral blood mononuclear cells -- PBMC-derived T cells -- Dendritic Cells -- Co-culture Caco-2/ immune cells -- Enteroendocrine Cell Models: General introduction -- STC-1 cells -- NCI-H716 cells -- Murine GLUTag cells -- In vitro intestinal tissue models: General introduction -- Intestinal crypt organoids as experimental models -- Porcine ex vivo intestinal segment model -- Ussing chamber -- In vitro fermentation models: General Introduction -- One compartment fermentation model -- The TNO in vitro model of the colon - TIM-2 -- The Simulator of the Human Intestinal Microbial Ecosystem – SHIME -- The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI.

This book describes in vitro and ex vivo models that can be employed to investigate effects of digested food products on the GIT, or specific components thereof. Many such models exist and include, for example, those used to study digestion and fermentation in the small and large intestine, to investigate absorption (e.g. Ussing chamber, epithelial cell systems), and to research the immune and enteroendocrine responses (e.g. macrophages, dendritic cells, co-cultures) In each case, these respective assays and models are discussed, and tips and tricks concerning their proper use are given. The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest. The book highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated, and highlights the strengths and weaknesses of the various assays. It is also an important resource for under-graduate students in the 'food and health' arena.

ISBN: 9783319161044 (electronic bk.)

Standard No.: 10.1007/978-3-319-16104-4doiSubjects--Topical Terms:

317318
Gastrointestinal system
--Microbiology.

LC Class. No.: QR171.G29

Dewey Class. No.: 612.3

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245 0 4 $a The impact of food bioactives on health $h [electronic resource] : $b in vitro and ex vivo models / $c edited by Kitty Verhoeckx ... [et al.].
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300 $a xvii, 338 p. : $b ill., digital ; $c 24 cm.
505 0 $a Introduction -- Gastrointestinal digestion models, general introduction -- Static digestion models general introduction -- InfoGest consensus method -- Approaches to static digestion models -- Dynamic digestion models general introduction -- The TNO gastro-Intestinal Model (TIM) -- Dynamic Gastric Model (DGM) -- Human Gastric Simulator (Riddet model) -- The DIDGI System -- General introduction to cells, cell lines and cell culture -- Epithelial cell models; General introduction -- Caco-2 cell line -- HT29 cell line -- The IPEC-J2 cell line -- Co-cultivation of Caco-2 and HT-29MT -- Innate and adaptive immune cells; General introduction -- THP-1 and U937 cells -- Peripheral blood mononuclear cells -- PBMC-derived T cells -- Dendritic Cells -- Co-culture Caco-2/ immune cells -- Enteroendocrine Cell Models: General introduction -- STC-1 cells -- NCI-H716 cells -- Murine GLUTag cells -- In vitro intestinal tissue models: General introduction -- Intestinal crypt organoids as experimental models -- Porcine ex vivo intestinal segment model -- Ussing chamber -- In vitro fermentation models: General Introduction -- One compartment fermentation model -- The TNO in vitro model of the colon - TIM-2 -- The Simulator of the Human Intestinal Microbial Ecosystem – SHIME -- The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI.
520 $a This book describes in vitro and ex vivo models that can be employed to investigate effects of digested food products on the GIT, or specific components thereof. Many such models exist and include, for example, those used to study digestion and fermentation in the small and large intestine, to investigate absorption (e.g. Ussing chamber, epithelial cell systems), and to research the immune and enteroendocrine responses (e.g. macrophages, dendritic cells, co-cultures) In each case, these respective assays and models are discussed, and tips and tricks concerning their proper use are given. The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest. The book highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated, and highlights the strengths and weaknesses of the various assays. It is also an important resource for under-graduate students in the 'food and health' arena.
650 0 $a Gastrointestinal system $x Microbiology. $3 317318
650 0 $a Digestion. $3 515605
650 0 $a Food |x Biotechnology. $3 719114
650 0 $a Bioactive compounds. $3 251649
650 1 4 $a Life Sciences. $3 273679
650 2 4 $a Food Microbiology. $3 235295
650 2 4 $a Food Science. $3 274110
650 2 4 $a Human Physiology. $3 274509
700 1 $a Verhoeckx, Kitty. $3 719113
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-16104-4
950 $a Biomedical and Life Sciences (Springer-11642)