國立高雄大學圖資館 |

Language: English

Back

Biomolecular interfacesinteractions,...

Fernandez Stigliano, Ariel.

Biomolecular interfacesinteractions, functions and drug design /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Biomolecular interfacesby Ariel Fernandez Stigliano.
Reminder of title:	interactions, functions and drug design /
Author:	Fernandez Stigliano, Ariel.
Published:	Cham :Springer International Publishing :2015.
Description:	xix, 372 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Biomolecules.
Online resource:	http://dx.doi.org/10.1007/978-3-319-16850-0
ISBN:	9783319168500 (electronic bk.)

Biomolecular interfacesinteractions, functions and drug design /
Fernandez Stigliano, Ariel.

Biomolecular interfacesinteractions, functions and drug design /[electronic resource] :by Ariel Fernandez Stigliano. - Cham :Springer International Publishing :2015. - xix, 372 p. :ill. (some col.), digital ;24 cm.

The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems.

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

ISBN: 9783319168500 (electronic bk.)

Standard No.: 10.1007/978-3-319-16850-0doiSubjects--Topical Terms:

194433
Biomolecules.

LC Class. No.: QP514.2

Dewey Class. No.: 572.33

Biomolecular interfacesinteractions, functions and drug design /
LDR:03360nmm a2200313 a 4500 001 465407
003 DE-He213
005 20151104155917.0
006 m d
007 cr nn 008maaau
008 151222s2015 gw s 0 eng d
020 $a 9783319168500 (electronic bk.)
020 $a 9783319168494 (paper)
024 7 $a 10.1007/978-3-319-16850-0 $2 doi
035 $a 978-3-319-16850-0
040 $a GP $c GP
041 0 $a eng
050 4 $a QP514.2
072 7 $a PSBC $2 bicssc
072 7 $a SCI007000 $2 bisacsh
082 0 4 $a 572.33 $2 23
090 $a QP514.2 $b .F363 2015
100 1 $a Fernandez Stigliano, Ariel. $3 719120
245 1 0 $a Biomolecular interfaces $h [electronic resource] : $b interactions, functions and drug design / $c by Ariel Fernandez Stigliano.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a xix, 372 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems.
520 $a The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.
650 0 $a Biomolecules. $3 194433
650 0 $a Biological interfaces. $3 203100
650 1 4 $a Life Sciences. $3 273679
650 2 4 $a Protein-Ligand Interactions. $3 348845
650 2 4 $a Membrane Biology. $3 384426
650 2 4 $a Molecular Medicine. $3 273932
650 2 4 $a Pharmaceutical Sciences/Technology. $3 338426
650 2 4 $a Biophysics and Biological Physics. $3 376965
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-16850-0
950 $a Biomedical and Life Sciences (Springer-11642)