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Parasitic helminthstargets, screens,...
~
Caffrey, Conor R.
Parasitic helminthstargets, screens, drugs and vaccines /
Record Type:
Electronic resources : Monograph/item
Title/Author:
Parasitic helminthsedited by Conor R. Caffrey.
Reminder of title:
targets, screens, drugs and vaccines /
other author:
Caffrey, Conor R.
Published:
Weinheim, Germany :Wiley-VCH,2012.
Description:
1 online resource (xxiii, 516 p. :)ill. (some col.).
Subject:
Helminths.
Online resource:
http://onlinelibrary.wiley.com/book/10.1002/9783527652969
ISBN:
9783527652969 (electronic bk.)
Parasitic helminthstargets, screens, drugs and vaccines /
Parasitic helminths
targets, screens, drugs and vaccines /[electronic resource] :edited by Conor R. Caffrey. - Weinheim, Germany :Wiley-VCH,2012. - 1 online resource (xxiii, 516 p. :)ill. (some col.). - Drug discovery in infectious diseases ;v. 3. - Drug discovery in infectious diseases ;v. 4..
Includes bibliographical references and index.
Part one: targets -- Ligand-gated ion channels as targets for anthelmintic drugs: past, current, and future perspectives -- How relevant is Caenorhabditis elegans as a model for the analysis of parasitic nematode biology? -- Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets -- Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies -- Harnessing genomic technologies to explore the molecular biology of liver flukes-major implications for fundamental and applied research -- RNA interference: a potential discovery tool for therapeutic targets of parasitic nematodes -- RNA interference as a tool for drug discovery in parasitic flatworms -- Part two: screens -- Mechanism-based screening strategies for anthelmintic discovery -- Identification and profiling of nematicidal compounds in veterinary parasitology -- Quantitative high-content screening-based drug discovery against helmintic diseases -- Use of rodent models in the discovery of novel anthelmintics -- To kill a mocking worm: strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery -- Part three: drugs -- Anthelmintic drugs: tools and shortcuts for the long road from discovery to product -- Antinematodal drugs: modes of action and resistance: and worms will not come to thee (Shakespeare: Cymbeline: iv, ii) -- Drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes -- Promise of Bacillus thuringiensis crystal proteins as anthelmintics -- Monepantel: from discovery to mode of action -- Discovery, mode of action, and commercialization of derquantel -- Praziquantel: too good to be replaced? -- Drug discovery for trematodiases: challenges and progress -- Part four: vaccines -- Barefoot thru' the valley of darkness: preclinical development of a human hookworm vaccine -- Vaccines linked to chemotherapy: a new approach to control helminth infections -- Antifilarial vaccine development: present and future approaches -- Proteases as vaccines against gastrointestinal nematode parasites of sheep and cattle -- Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates -- Sm14 Schistosoma mansoni fatty acid-binding protein: molecular basis for an antihelminth vaccine -- Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics -- Prospects for immunoprophylaxis against Fasciola hepatica (liver fluke) -- Vaccines against cestode parasites.
ISBN: 9783527652969 (electronic bk.)Subjects--Topical Terms:
571541
Helminths.
LC Class. No.: RC119.7 / .P37 2012eb
Dewey Class. No.: 616.96061
Parasitic helminthstargets, screens, drugs and vaccines /
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Parasitic helminths
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[electronic resource] :
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targets, screens, drugs and vaccines /
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edited by Conor R. Caffrey.
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Weinheim, Germany :
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Wiley-VCH,
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2012.
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1 online resource (xxiii, 516 p. :)
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ill. (some col.).
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Drug discovery in infectious diseases ;
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v. 3
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Includes bibliographical references and index.
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Part one: targets -- Ligand-gated ion channels as targets for anthelmintic drugs: past, current, and future perspectives -- How relevant is Caenorhabditis elegans as a model for the analysis of parasitic nematode biology? -- Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets -- Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies -- Harnessing genomic technologies to explore the molecular biology of liver flukes-major implications for fundamental and applied research -- RNA interference: a potential discovery tool for therapeutic targets of parasitic nematodes -- RNA interference as a tool for drug discovery in parasitic flatworms -- Part two: screens -- Mechanism-based screening strategies for anthelmintic discovery -- Identification and profiling of nematicidal compounds in veterinary parasitology -- Quantitative high-content screening-based drug discovery against helmintic diseases -- Use of rodent models in the discovery of novel anthelmintics -- To kill a mocking worm: strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery -- Part three: drugs -- Anthelmintic drugs: tools and shortcuts for the long road from discovery to product -- Antinematodal drugs: modes of action and resistance: and worms will not come to thee (Shakespeare: Cymbeline: iv, ii) -- Drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes -- Promise of Bacillus thuringiensis crystal proteins as anthelmintics -- Monepantel: from discovery to mode of action -- Discovery, mode of action, and commercialization of derquantel -- Praziquantel: too good to be replaced? -- Drug discovery for trematodiases: challenges and progress -- Part four: vaccines -- Barefoot thru' the valley of darkness: preclinical development of a human hookworm vaccine -- Vaccines linked to chemotherapy: a new approach to control helminth infections -- Antifilarial vaccine development: present and future approaches -- Proteases as vaccines against gastrointestinal nematode parasites of sheep and cattle -- Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates -- Sm14 Schistosoma mansoni fatty acid-binding protein: molecular basis for an antihelminth vaccine -- Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics -- Prospects for immunoprophylaxis against Fasciola hepatica (liver fluke) -- Vaccines against cestode parasites.
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Description based on print version record.
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Helminths.
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Parasites.
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Parasitic diseases
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Treatment.
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http://onlinelibrary.wiley.com/book/10.1002/9783527652969
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電子館藏
1圖書
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EB RC119.7 P222 2012
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http://onlinelibrary.wiley.com/book/10.1002/9783527652969
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