國立高雄大學圖資館 |

Language: English

Back

SH domainsstructure, mechanisms and ...

Kurochkina, Natalya.

SH domainsstructure, mechanisms and applications /

Record Type:	Electronic resources : Monograph/item
Title/Author:	SH domainsedited by Natalya Kurochkina.
Reminder of title:	structure, mechanisms and applications /
other author:	Kurochkina, Natalya.
Published:	Cham :Springer International Publishing :2015.
Description:	viii, 253 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Protein-tyrosine kinase.
Online resource:	http://dx.doi.org/10.1007/978-3-319-20098-9
ISBN:	9783319200989 (electronic bk.)

SH domainsstructure, mechanisms and applications /
SH domainsstructure, mechanisms and applications /[electronic resource] :edited by Natalya Kurochkina. - Cham :Springer International Publishing :2015. - viii, 253 p. :ill., digital ;24 cm.

SH3 Domains as Suitable Models to Study Amyloid Aggregation -- SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking -- Versatility of SH3 Domains in the Cellular Machinery -- Structure-Function Relationship of Bacterial SH3 Domains -- Activation of PI3K by Thyroid Hormone Nuclear Receptors -- SH Domains' Interaction with SliMs: Maximizing Adaptivity of Signaling Networks -- SH Domains and Epidermal Growth Factor Receptor -- SH2 Domain Structures and Interactions -- Cytoskeletal Signaling by Src Homology Domain-Containing Adaptor Proteins -- Structure and Function of Jak3- SH2 Domain -- Helical Assemblies and SH Domains.

This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.

ISBN: 9783319200989 (electronic bk.)

Standard No.: 10.1007/978-3-319-20098-9doiSubjects--Topical Terms:

468462
Protein-tyrosine kinase.

LC Class. No.: QP606.P78

Dewey Class. No.: 572.6

SH domainsstructure, mechanisms and applications /
LDR:02703nmm a2200313 a 4500 001 472498
003 DE-He213
005 20160219085437.0
006 m d
007 cr nn 008maaau
008 160316s2015 gw s 0 eng d
020 $a 9783319200989 (electronic bk.)
020 $a 9783319200972 (paper)
024 7 $a 10.1007/978-3-319-20098-9 $2 doi
035 $a 978-3-319-20098-9
040 $a GP $c GP
041 0 $a eng
050 4 $a QP606.P78
072 7 $a PSBC $2 bicssc
072 7 $a SCI007000 $2 bisacsh
082 0 4 $a 572.6 $2 23
090 $a QP606.P78 $b S523 2015
245 0 0 $a SH domains $h [electronic resource] : $b structure, mechanisms and applications / $c edited by Natalya Kurochkina.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a viii, 253 p. : $b ill., digital ; $c 24 cm.
505 0 $a SH3 Domains as Suitable Models to Study Amyloid Aggregation -- SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking -- Versatility of SH3 Domains in the Cellular Machinery -- Structure-Function Relationship of Bacterial SH3 Domains -- Activation of PI3K by Thyroid Hormone Nuclear Receptors -- SH Domains' Interaction with SliMs: Maximizing Adaptivity of Signaling Networks -- SH Domains and Epidermal Growth Factor Receptor -- SH2 Domain Structures and Interactions -- Cytoskeletal Signaling by Src Homology Domain-Containing Adaptor Proteins -- Structure and Function of Jak3- SH2 Domain -- Helical Assemblies and SH Domains.
520 $a This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.
650 0 $a Protein-tyrosine kinase. $3 468462
650 0 $a Amino acids. $3 683490
650 1 4 $a Life Sciences. $3 273679
650 2 4 $a Protein Science. $3 376428
650 2 4 $a Protein Structure. $3 348844
650 2 4 $a Protein-Ligand Interactions. $3 348845
650 2 4 $a Cell Biology. $3 274165
700 1 $a Kurochkina, Natalya. $3 727674
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-20098-9
950 $a Biomedical and Life Sciences (Springer-11642)