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ADAMTS13biology and disease /

Rodgers, George M.

ADAMTS13biology and disease /

Record Type:	Electronic resources : Monograph/item
Title/Author:	ADAMTS13edited by George M. Rodgers.
Reminder of title:	biology and disease /
other author:	Rodgers, George M.
Published:	Cham :Springer International Publishing :2015.
Description:	x, 186 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Biochemistry.
Online resource:	http://dx.doi.org/10.1007/978-3-319-08717-7
ISBN:	9783319087177$q(electronic bk.)

ADAMTS13biology and disease /
ADAMTS13biology and disease /[electronic resource] :edited by George M. Rodgers. - Cham :Springer International Publishing :2015. - x, 186 p. :ill., digital ;24 cm.

1. A13: Structure and function -- 2. A13: The von Willebrand factor cleaving protease -- 3. A13: Angiogenesis and other biologic activities -- 4. A13: Assays -- 5. Inherited A13 deficiency (Upshaw-Schulman Syndrome) -- 6. Acquired A13 deficiency (TTP) -- 7. Related thrombotic microangiopathies -- 8. Future directions.

This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor) Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.

ISBN: 9783319087177$q(electronic bk.)

Standard No.: 10.1007/978-3-319-08717-7doiSubjects--Topical Terms:

188609
Biochemistry.

LC Class. No.: QP551

Dewey Class. No.: 572

ADAMTS13biology and disease /
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245 0 0 $a ADAMTS13 $h [electronic resource] : $b biology and disease / $c edited by George M. Rodgers.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a x, 186 p. : $b ill., digital ; $c 24 cm.
505 0 $a 1. A13: Structure and function -- 2. A13: The von Willebrand factor cleaving protease -- 3. A13: Angiogenesis and other biologic activities -- 4. A13: Assays -- 5. Inherited A13 deficiency (Upshaw-Schulman Syndrome) -- 6. Acquired A13 deficiency (TTP) -- 7. Related thrombotic microangiopathies -- 8. Future directions.
520 $a This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor) Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
650 0 $a Biochemistry. $3 188609
650 0 $a Cytology. $3 189001
650 0 $a Thrombotic thrombocytopenic purpura. $3 728927
650 0 $a Proteomics. $3 220403
650 0 $a Proteolytic enzymes. $3 193678
650 1 4 $a Life Sciences. $3 273679
650 2 4 $a Hematology. $3 274899
650 2 4 $a Cell Biology. $3 274165
700 1 $a Rodgers, George M. $3 711531
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-08717-7
950 $a Biomedical and Life Sciences (Springer-11642)