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Molecular oncology testing for solid...

Dumur, Catherine Isabelle.

Molecular oncology testing for solid tumorsa pragmatic approach /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular oncology testing for solid tumorsedited by Michael Ola Idowu, Catherine Isabelle Dumur, Carleton Theodore Garrett.
Reminder of title:	a pragmatic approach /
other author:	Idowu, Michael Ola.
Published:	Cham :Springer International Publishing :2015.
Description:	ix, 742 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	CancerMolecular diagnosis.
Online resource:	http://dx.doi.org/10.1007/978-3-319-16304-8
ISBN:	9783319163048$q(electronic bk.)

Molecular oncology testing for solid tumorsa pragmatic approach /
Molecular oncology testing for solid tumorsa pragmatic approach /[electronic resource] :edited by Michael Ola Idowu, Catherine Isabelle Dumur, Carleton Theodore Garrett. - Cham :Springer International Publishing :2015. - ix, 742 p. :ill. (some col.), digital ;24 cm.

Part I. Overview of Basic Cellular Biology -- 1. Normal molecular biology and definition of terms -- 2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins -- 3. Standard nomenclature - introduction and brief overview -- Part II. Molecular Oncology Methodology -- 4. General principles of Oncology testing -- 5. Molecular methodologies -- 6. General principles of validating a molecular test -- Part III. Molecular testing in Solid Tumors -- 7. Lung and mediastinum -- 8. Breast -- 9. Head and neck (salivary glands) -- 10. Thyroid and parathyroid (endocrine) -- 11. Gastrointestinal and Pancreatobiliary -- 12. Soft tissue -- 13. Genitourinary system -- 14. Central Nervous System -- 15. Skin and adnexa -- 16. Common Hereditary Cancer Syndromes -- Part IV. The future is here -- 17. Application of next generation sequencing -- Part V. Quality Assurance and Regulatory affairs -- 18. Quality Assurance - pre-analytic, analytic and post-analytic -- 19. Regulatory affairs (including accreditation) -- 20. Coding and re-imbursement.

This text is designed to present an up-to-date practical approach to molecular testing in an easy to understand format. Emphasis is placed on molecular testing for solid tumors, while underscoring the following: i) the crucial role of pathologists in ensuring specimen adequacy for molecular testing; ii) current molecular assays/platforms (including next-generation sequencing); iii) clinical utility and limitations of biomarkers to enable effective communication with clinicians; iv) the importance of quality assurance metrics to ensure accurate and reproducible results; v) pitfalls in test interpretation (that may lead to False Positive or False Negative interpretations); vi) importance of using standard nomenclature, including exercises on variant (mutation) description; vii) regulatory affairs, coding and reimbursement. The uniqueness of this text is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. Molecular Oncology Testing for Solid Tumors will enable readers to easily understand the Ordering, Processing, Interpretation, Reporting and the clinical Application (OPIRA) process of molecular testing or biomarkers.

ISBN: 9783319163048$q(electronic bk.)

Standard No.: 10.1007/978-3-319-16304-8doiSubjects--Topical Terms:

221222
Cancer
--Molecular diagnosis.

LC Class. No.: RC270

Dewey Class. No.: 616.994075

Molecular oncology testing for solid tumorsa pragmatic approach /
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505 0 $a Part I. Overview of Basic Cellular Biology -- 1. Normal molecular biology and definition of terms -- 2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins -- 3. Standard nomenclature - introduction and brief overview -- Part II. Molecular Oncology Methodology -- 4. General principles of Oncology testing -- 5. Molecular methodologies -- 6. General principles of validating a molecular test -- Part III. Molecular testing in Solid Tumors -- 7. Lung and mediastinum -- 8. Breast -- 9. Head and neck (salivary glands) -- 10. Thyroid and parathyroid (endocrine) -- 11. Gastrointestinal and Pancreatobiliary -- 12. Soft tissue -- 13. Genitourinary system -- 14. Central Nervous System -- 15. Skin and adnexa -- 16. Common Hereditary Cancer Syndromes -- Part IV. The future is here -- 17. Application of next generation sequencing -- Part V. Quality Assurance and Regulatory affairs -- 18. Quality Assurance - pre-analytic, analytic and post-analytic -- 19. Regulatory affairs (including accreditation) -- 20. Coding and re-imbursement.
520 $a This text is designed to present an up-to-date practical approach to molecular testing in an easy to understand format. Emphasis is placed on molecular testing for solid tumors, while underscoring the following: i) the crucial role of pathologists in ensuring specimen adequacy for molecular testing; ii) current molecular assays/platforms (including next-generation sequencing); iii) clinical utility and limitations of biomarkers to enable effective communication with clinicians; iv) the importance of quality assurance metrics to ensure accurate and reproducible results; v) pitfalls in test interpretation (that may lead to False Positive or False Negative interpretations); vi) importance of using standard nomenclature, including exercises on variant (mutation) description; vii) regulatory affairs, coding and reimbursement. The uniqueness of this text is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. Molecular Oncology Testing for Solid Tumors will enable readers to easily understand the Ordering, Processing, Interpretation, Reporting and the clinical Application (OPIRA) process of molecular testing or biomarkers.
650 0 $a Cancer $x Molecular diagnosis. $3 221222
650 0 $a Cancer $x Molecular aspects. $3 221221
650 1 4 $a Medicine & Public Health. $3 273799
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650 2 4 $a Oncology. $3 195181
700 1 $a Idowu, Michael Ola. $3 729290
700 1 $a Dumur, Catherine Isabelle. $3 729291
700 1 $a Garrett, Carleton Theodore. $3 729292
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856 4 0 $u http://dx.doi.org/10.1007/978-3-319-16304-8
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