國立高雄大學圖資館 |

Language: English

Back

Synthesis of diverse BODIPY dyes and...

Abeywardana, Sewwandi.

Synthesis of diverse BODIPY dyes and water solubilization strategies.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis of diverse BODIPY dyes and water solubilization strategies.
Author:	Abeywardana, Sewwandi.
Description:	128 p.
Notes:	Source: Masters Abstracts International, Volume: 55-02.
Notes:	Adviser: Michael P. Schramm.
Contained By:	Masters Abstracts International55-02(E).
Subject:	Organic chemistry.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1600577
ISBN:	9781339096261

Synthesis of diverse BODIPY dyes and water solubilization strategies.
Abeywardana, Sewwandi.

Synthesis of diverse BODIPY dyes and water solubilization strategies. - 128 p.

Source: Masters Abstracts International, Volume: 55-02.

Thesis (M.S.)--California State University, Long Beach, 2015.

We report the synthesis and properties of a variety of substituted 4,4-difluoro-4-bora-3a,4a-diaza- s-indacene (BODIPY), with potential to be developed into biological probes. The substituents at 2, 6-positions on the BODIPY were changed by the use of corresponding pyrrole building blocks. Electron-donating and withdrawing substituents were introduced on to the BODIPY core in order to study their effects on the photochemical properties. Different strategies were carried out to saponify the ester groups on the BODIPY to obtain the carboxylic acid derivatives. These carboxylic acid groups were expected to increase the water-solubility of the BODIPY as well as facilitate the bio-conjugation. However, due to incompatibility of the BODIPY core to the reaction conditions, targeted products were not obtained. In couple of cases, the meso position was functionalized by 4-formylbenzoic acid to enable the bio-conjugation of new dyes. Alternative routes to synthesize carboxylic acid derivatives of the novel BODIPYs are under investigation.

ISBN: 9781339096261Subjects--Topical Terms:

708640
Organic chemistry.

Synthesis of diverse BODIPY dyes and water solubilization strategies.
LDR:01880nmm a2200265 4500 001 476031
005 20160418090142.5
008 160517s2015 ||||||||||||||||| ||eng d
020 $a 9781339096261
035 $a (MiAaPQ)AAI1600577
035 $a AAI1600577
040 $a MiAaPQ $c MiAaPQ
100 1 $a Abeywardana, Sewwandi. $3 730269
245 1 0 $a Synthesis of diverse BODIPY dyes and water solubilization strategies.
300 $a 128 p.
500 $a Source: Masters Abstracts International, Volume: 55-02.
500 $a Adviser: Michael P. Schramm.
502 $a Thesis (M.S.)--California State University, Long Beach, 2015.
520 $a We report the synthesis and properties of a variety of substituted 4,4-difluoro-4-bora-3a,4a-diaza- s-indacene (BODIPY), with potential to be developed into biological probes. The substituents at 2, 6-positions on the BODIPY were changed by the use of corresponding pyrrole building blocks. Electron-donating and withdrawing substituents were introduced on to the BODIPY core in order to study their effects on the photochemical properties. Different strategies were carried out to saponify the ester groups on the BODIPY to obtain the carboxylic acid derivatives. These carboxylic acid groups were expected to increase the water-solubility of the BODIPY as well as facilitate the bio-conjugation. However, due to incompatibility of the BODIPY core to the reaction conditions, targeted products were not obtained. In couple of cases, the meso position was functionalized by 4-formylbenzoic acid to enable the bio-conjugation of new dyes. Alternative routes to synthesize carboxylic acid derivatives of the novel BODIPYs are under investigation.
590 $a School code: 6080.
650 4 $a Organic chemistry. $3 708640
690 $a 0490
710 2 $a California State University, Long Beach. $b Chemistry and Biochemistry. $3 730270
773 0 $t Masters Abstracts International $g 55-02(E).
790 $a 6080
791 $a M.S.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1600577