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Novel chemical tools to study ion ch...

Ahern, Christopher.

Novel chemical tools to study ion channel biology

Record Type:	Electronic resources : Monograph/item
Title/Author:	Novel chemical tools to study ion channel biologyedited by Christopher Ahern, Stephan Pless.
other author:	Ahern, Christopher.
Published:	New York, NY :Springer New York :2015.
Description:	viii, 154 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Ion channels.
Online resource:	http://dx.doi.org/10.1007/978-1-4939-2845-3
ISBN:	9781493928453$q(electronic bk.)

Novel chemical tools to study ion channel biology
Novel chemical tools to study ion channel biology[electronic resource] /edited by Christopher Ahern, Stephan Pless. - New York, NY :Springer New York :2015. - viii, 154 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v.8690065-2598 ;. - Advances in experimental medicine and biology ;946..

This volume describes chemical approaches to assess ion channel structure, function and pharmacology. Topics discussed include the use of engineered ionizable side chains to obtain information on permeation pathways and the local environment; the modification of engineered cysteine side chains, including cysteine scanning mutagenesis and the attachment of fluorescent probes and bio-reactive tethers; and the nascent use of genetic code expansion, evaluating its applications to ion channel and membrane proteins. This comprehensive text provides multifaceted perspectives on the great diversity of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox to study ion channel biology. Capturing the contributions and innovations of renowned laboratory researchers in transmembrane protein study for the first time, this book is comprehensive in scope. It covers a wide array of experimental approaches: photochemistry, novel biological tools, and innovative spectroscopy, all combined with traditional techniques of electrophysiology and molecular biology. Novel Chemical Tools to Study Ion Channel Biology, part of the bestselling Advances in Experimental Medicine and Biology series is ideal for researchers and advanced students interested in biochemistry, biophysics, fluorometry, electrophysiology, and chemical biology.

ISBN: 9781493928453$q(electronic bk.)

Standard No.: 10.1007/978-1-4939-2845-3doiSubjects--Topical Terms:

195439
Ion channels.

LC Class. No.: QH603.I54

Dewey Class. No.: 571.64

Novel chemical tools to study ion channel biology
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520 $a This volume describes chemical approaches to assess ion channel structure, function and pharmacology. Topics discussed include the use of engineered ionizable side chains to obtain information on permeation pathways and the local environment; the modification of engineered cysteine side chains, including cysteine scanning mutagenesis and the attachment of fluorescent probes and bio-reactive tethers; and the nascent use of genetic code expansion, evaluating its applications to ion channel and membrane proteins. This comprehensive text provides multifaceted perspectives on the great diversity of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox to study ion channel biology. Capturing the contributions and innovations of renowned laboratory researchers in transmembrane protein study for the first time, this book is comprehensive in scope. It covers a wide array of experimental approaches: photochemistry, novel biological tools, and innovative spectroscopy, all combined with traditional techniques of electrophysiology and molecular biology. Novel Chemical Tools to Study Ion Channel Biology, part of the bestselling Advances in Experimental Medicine and Biology series is ideal for researchers and advanced students interested in biochemistry, biophysics, fluorometry, electrophysiology, and chemical biology.
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650 0 $a Electrophysiology. $3 189030
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