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Admixture dynamics, natural selectio...

Jin, Wenfei.

Admixture dynamics, natural selection and diseases in admixed populations

Record Type:	Electronic resources : Monograph/item
Title/Author:	Admixture dynamics, natural selection and diseases in admixed populationsby Wenfei Jin.
Author:	Jin, Wenfei.
Published:	Dordrecht :Springer Netherlands :2015.
Description:	xix, 114 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Adaptation (Biology)
Online resource:	http://dx.doi.org/10.1007/978-94-017-7408-6
ISBN:	9789401774086$q(electronic bk.)

Admixture dynamics, natural selection and diseases in admixed populations
Jin, Wenfei.

Admixture dynamics, natural selection and diseases in admixed populations[electronic resource] /by Wenfei Jin. - Dordrecht :Springer Netherlands :2015. - xix, 114 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Distribution of length of ancestral chromosomal segments in admixed genomes -- Exploring population admixture dynamics via distribution of LACS -- Genome-wide search for signatures of natural selection in African Americans -- Complex selective forces shaping the genes underlying human diseases -- Materials and Methods.

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

ISBN: 9789401774086$q(electronic bk.)

Standard No.: 10.1007/978-94-017-7408-6doiSubjects--Topical Terms:

194469
Adaptation (Biology)

LC Class. No.: QH546 / .J56 2015

Dewey Class. No.: 578.4

Admixture dynamics, natural selection and diseases in admixed populations
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520 $a In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
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