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Synthetic and biophysical studies on...

Powell, Kimberley Jade.

Synthetic and biophysical studies on the tridachiahydropyrone family of natural products

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthetic and biophysical studies on the tridachiahydropyrone family of natural productsby Kimberley Jade Powell.
Author:	Powell, Kimberley Jade.
Published:	Cham :Springer International Publishing :2016.
Description:	xix, 136 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Natural productsSynthesis.
Online resource:	http://dx.doi.org/10.1007/978-3-319-22069-7
ISBN:	9783319220697$q(electronic bk.)

Synthetic and biophysical studies on the tridachiahydropyrone family of natural products
Powell, Kimberley Jade.

Synthetic and biophysical studies on the tridachiahydropyrone family of natural products[electronic resource] /by Kimberley Jade Powell. - Cham :Springer International Publishing :2016. - xix, 136 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Synthesis of the Tridachiahydropyrones and their Biomimetic Precursors -- Interactions of the Tridachiahydropyrones with Model Membrane Systems: Biophysical Studies -- Investigations into the Photoprotective and Antioxidant Properties of the Tridachiahydropyrones -- Summary and Conclusions -- Experimental -- Synthesis of Alkenyl Nitriles by the Palladium-Catalysed Cyanation of Vinyl Halides with Acetone Cyanohydrin.

This thesis addresses fundamental scientific questions such as: How are complex natural products synthesized in vivo? Can we replicate these conditions in a laboratory environment? What is the biological function of such secondary metabolites? What are the biological origins of chirality? These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs - the tridachiahydropyrones. The work has achieved: Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.

ISBN: 9783319220697$q(electronic bk.)

Standard No.: 10.1007/978-3-319-22069-7doiSubjects--Topical Terms:

277952
Natural products
--Synthesis.

LC Class. No.: QD415.P69

Dewey Class. No.: 572

Synthetic and biophysical studies on the tridachiahydropyrone family of natural products
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520 $a This thesis addresses fundamental scientific questions such as: How are complex natural products synthesized in vivo? Can we replicate these conditions in a laboratory environment? What is the biological function of such secondary metabolites? What are the biological origins of chirality? These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs - the tridachiahydropyrones. The work has achieved: Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.
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