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B cell receptor signaling

Kurosaki, Tomohiro.

B cell receptor signaling

Record Type:	Electronic resources : Monograph/item
Title/Author:	B cell receptor signalingedited by Tomohiro Kurosaki, Jurgen Wienands.
other author:	Kurosaki, Tomohiro.
Published:	Cham :Springer International Publishing :2016.
Description:	viii, 231 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	B cellsReceptors.
Online resource:	http://dx.doi.org/10.1007/978-3-319-26133-1
ISBN:	9783319261331$q(electronic bk.)

B cell receptor signaling
B cell receptor signaling[electronic resource] /edited by Tomohiro Kurosaki, Jurgen Wienands. - Cham :Springer International Publishing :2016. - viii, 231 p. :ill., digital ;24 cm. - Current topics in microbiology and immunology,v.3930070-217X ;. - Current topics in microbiology and immunology ;v.351..

Assembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology.

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

ISBN: 9783319261331$q(electronic bk.)

Standard No.: 10.1007/978-3-319-26133-1doiSubjects--Topical Terms:

738703
B cells
--Receptors.

LC Class. No.: QR185.8.B15

Dewey Class. No.: 571.967

B cell receptor signaling
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520 $a This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
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