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Quasispeciesfrom theory to experimen...

Domingo, Esteban.

Quasispeciesfrom theory to experimental systems /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Quasispeciesedited by Esteban Domingo, Peter Schuster.
Reminder of title:	from theory to experimental systems /
other author:	Domingo, Esteban.
Published:	Cham :Springer International Publishing :2016.
Description:	xiv, 357 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Virology.
Online resource:	http://dx.doi.org/10.1007/978-3-319-23898-2
ISBN:	9783319238982$q(electronic bk.)

Quasispeciesfrom theory to experimental systems /
Quasispeciesfrom theory to experimental systems /[electronic resource] :edited by Esteban Domingo, Peter Schuster. - Cham :Springer International Publishing :2016. - xiv, 357 p. :ill., digital ;24 cm. - Current topics in microbiology and immunology,v.3920070-217X ;. - Current topics in microbiology and immunology ;v.351..

What is a quasispecies?- Historical origins and current scope -- The nucleation of semantic information in prebiotic matter -- Evolution of RNA-based networks -- Quasispecies on fitness landscapes -- Mathematical models of quasispecies theory and exact results for the dynamics -- Theoretical Models of Generalized Quasispecies -- Theories of lethal mutagenesis: from error catastrophe to lethal defection -- Estimating fitness of viral quasispecies from next-generation sequencing data -- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models -- Cooperative Interaction within RNA Virus Mutant Spectra -- Arenavirus Quasispecies And Their Biological Implications -- Models of viral population dynamics -- Fidelity variants and RNA quasispecies -- Antiviral strategies based on lethal mutagenesis and error threshold.

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

ISBN: 9783319238982$q(electronic bk.)

Standard No.: 10.1007/978-3-319-23898-2doiSubjects--Topical Terms:

196498
Virology.

LC Class. No.: QR360

Dewey Class. No.: 579.2

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520 $a This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.
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