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Computational modelling of the human...

Skeby, Katrine Kirkeby.

Computational modelling of the human islet amyloid polypeptide

Record Type:	Electronic resources : Monograph/item
Title/Author:	Computational modelling of the human islet amyloid polypeptideby Katrine Kirkeby Skeby.
Author:	Skeby, Katrine Kirkeby.
Published:	Cham :Springer International Publishing :2016.
Description:	xvi, 118 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	AmyloidSimulation methods.
Online resource:	http://dx.doi.org/10.1007/978-3-319-20040-8
ISBN:	9783319200408$q(electronic bk.)

Computational modelling of the human islet amyloid polypeptide
Skeby, Katrine Kirkeby.

Computational modelling of the human islet amyloid polypeptide[electronic resource] /by Katrine Kirkeby Skeby. - Cham :Springer International Publishing :2016. - xvi, 118 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Amyloid and Amyloid Fibrils -- Computational Theory -- Imaging Agent Binding to Amyloid Protofibrils -- Determining the Aggregation Prone Structure of hiAPP -- Effect of Terminal Capping on Aggregation of Peptide Fragments -- Coarse Grained Study of Amyloid Protofibril Aggregation -- Conclusion and Perspectives.

This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins.

ISBN: 9783319200408$q(electronic bk.)

Standard No.: 10.1007/978-3-319-20040-8doiSubjects--Topical Terms:

747286
Amyloid
--Simulation methods.

LC Class. No.: QP552.A45

Dewey Class. No.: 572.68

Computational modelling of the human islet amyloid polypeptide
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245 1 0 $a Computational modelling of the human islet amyloid polypeptide $h [electronic resource] / $c by Katrine Kirkeby Skeby.
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300 $a xvi, 118 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Amyloid and Amyloid Fibrils -- Computational Theory -- Imaging Agent Binding to Amyloid Protofibrils -- Determining the Aggregation Prone Structure of hiAPP -- Effect of Terminal Capping on Aggregation of Peptide Fragments -- Coarse Grained Study of Amyloid Protofibril Aggregation -- Conclusion and Perspectives.
520 $a This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins.
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650 0 $a Proteins $x Metabolism $x Disorders $x Simulation methods. $3 747287
650 1 4 $a Chemistry. $3 188628
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650 2 4 $a Computer Applications in Chemistry. $3 273872
650 2 4 $a Bioorganic Chemistry. $3 275016
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950 $a Chemistry and Materials Science (Springer-11644)