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Sperm acrosome biogenesis and functi...

Buffone, Mariano G.

Sperm acrosome biogenesis and function during fertilization

Record Type:	Electronic resources : Monograph/item
Title/Author:	Sperm acrosome biogenesis and function during fertilizationedited by Mariano G. Buffone.
other author:	Buffone, Mariano G.
Published:	Cham :Springer International Publishing :2016.
Description:	vii, 172 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Acrosome reaction.
Online resource:	http://dx.doi.org/10.1007/978-3-319-30567-7
ISBN:	9783319305677$q(electronic bk.)

Sperm acrosome biogenesis and function during fertilization
Sperm acrosome biogenesis and function during fertilization[electronic resource] /edited by Mariano G. Buffone. - Cham :Springer International Publishing :2016. - vii, 172 p. :ill. (some col.), digital ;24 cm. - Advances in anatomy, embryology and cell biology,2200301-5556 ;. - Advances in anatomy, embryology and cell biology ;211..

Preface -- The acrosome reaction: a historical perspective -- The acrosomal matrix -- Role of ion channels in the sperm acrosome reaction -- The molecules of sperm exocytosis -- Sperm capacitation and acrosome reaction in mammalian sperm -- Lipid regulation of acrosome exocytosis -- Role of actin cytoskeleton during mammalian sperm acrosomal exocytosis -- Site of mammalian sperm acrosome reaction.

Over the last decades, acrosomal exocytosis (also called the "acrosome reaction") has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.

ISBN: 9783319305677$q(electronic bk.)

Standard No.: 10.1007/978-3-319-30567-7doiSubjects--Topical Terms:

748027
Acrosome reaction.

LC Class. No.: QL966

Dewey Class. No.: 571.8451

Sperm acrosome biogenesis and function during fertilization
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520 $a Over the last decades, acrosomal exocytosis (also called the "acrosome reaction") has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
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