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Protein tyrosine phosphatases in cancer

Neel, Benjamin G.

Protein tyrosine phosphatases in cancer

Record Type:	Electronic resources : Monograph/item
Title/Author:	Protein tyrosine phosphatases in canceredited by Benjamin G. Neel, Nicholas K. Tonks.
other author:	Neel, Benjamin G.
Published:	New York, NY :Springer New York :2016.
Description:	viii, 360 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer eBooks
Subject:	CancerMolecular aspects.
Online resource:	http://dx.doi.org/10.1007/978-1-4939-3649-6
ISBN:	9781493936496$q(electronic bk.)

Protein tyrosine phosphatases in cancer
Protein tyrosine phosphatases in cancer[electronic resource] /edited by Benjamin G. Neel, Nicholas K. Tonks. - New York, NY :Springer New York :2016. - viii, 360 p. :ill. (some col.), digital ;24 cm.

1 Introduction to the PTP Superfamily -- 2 Receptor PTPs in Cancer -- 3 Non-Receptor PTPs in Cancer -- 4 HP2 -- 5 C-PTP -- 6 PTP1B -- 7 PTP-PEST -- 8 Dual Specificity Phosphatases in Cancer -- 9 Phosphatase-dependent roles for PTEN in Cancer -- 10 Phosphatase-independent roles for PTEN in Cancer -- 11 PRL family members in Cancer -- 12 Cdc25 family -- 13 PTPs, metabolism and cancer -- 14 PTPs, metabolism and cancer -- 15 Current status of PTP-based therapeutics -- 16 Summary and Perspective.

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer, from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.

ISBN: 9781493936496$q(electronic bk.)

Standard No.: 10.1007/978-1-4939-3649-6doiSubjects--Topical Terms:

221221
Cancer
--Molecular aspects.

LC Class. No.: RC262

Dewey Class. No.: 616.994

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245 0 0 $a Protein tyrosine phosphatases in cancer $h [electronic resource] / $c edited by Benjamin G. Neel, Nicholas K. Tonks.
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300 $a viii, 360 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a 1 Introduction to the PTP Superfamily -- 2 Receptor PTPs in Cancer -- 3 Non-Receptor PTPs in Cancer -- 4 HP2 -- 5 C-PTP -- 6 PTP1B -- 7 PTP-PEST -- 8 Dual Specificity Phosphatases in Cancer -- 9 Phosphatase-dependent roles for PTEN in Cancer -- 10 Phosphatase-independent roles for PTEN in Cancer -- 11 PRL family members in Cancer -- 12 Cdc25 family -- 13 PTPs, metabolism and cancer -- 14 PTPs, metabolism and cancer -- 15 Current status of PTP-based therapeutics -- 16 Summary and Perspective.
520 $a This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer, from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.
650 0 $a Cancer $x Molecular aspects. $3 221221
650 0 $a Protein-tyrosine phosphatase. $3 758005
650 1 4 $a Biomedicine. $3 273648
650 2 4 $a Cancer Research. $3 273660
650 2 4 $a Cell Biology. $3 274165
650 2 4 $a Posttranslational Modification. $3 376429
700 1 $a Neel, Benjamin G. $3 758003
700 1 $a Tonks, Nicholas K. $3 758004
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-1-4939-3649-6
950 $a Biomedical and Life Sciences (Springer-11642)