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Defects in T cell trafficking and re...

Donnadieu, Emmanuel.

Defects in T cell trafficking and resistance to cancer immunotherapy

Record Type:	Electronic resources : Monograph/item
Title/Author:	Defects in T cell trafficking and resistance to cancer immunotherapyedited by Emmanuel Donnadieu.
other author:	Donnadieu, Emmanuel.
Published:	Cham :Springer International Publishing :2016.
Description:	viii, 199 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	CancerImmunotherapy.
Online resource:	http://dx.doi.org/10.1007/978-3-319-42223-7
ISBN:	9783319422237$q(electronic bk.)

Defects in T cell trafficking and resistance to cancer immunotherapy
Defects in T cell trafficking and resistance to cancer immunotherapy[electronic resource] /edited by Emmanuel Donnadieu. - Cham :Springer International Publishing :2016. - viii, 199 p. :ill., digital ;24 cm. - Resistance to targeted anti-cancer therapeutics,2196-5501. - Resistance to targeted anti-cancer therapeutics..

Introduction -- Basic rules of T cell migration -- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging -- Vascular normalization, T cell trafficking and anti-tumor immunity -- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts -- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic -- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy -- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors -- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors.

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

ISBN: 9783319422237$q(electronic bk.)

Standard No.: 10.1007/978-3-319-42223-7doiSubjects--Topical Terms:

201873
Cancer
--Immunotherapy.

LC Class. No.: RC271.I45

Dewey Class. No.: 616.99406

Defects in T cell trafficking and resistance to cancer immunotherapy
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245 0 0 $a Defects in T cell trafficking and resistance to cancer immunotherapy $h [electronic resource] / $c edited by Emmanuel Donnadieu.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a viii, 199 p. : $b ill., digital ; $c 24 cm.
490 1 $a Resistance to targeted anti-cancer therapeutics, $x 2196-5501
505 0 $a Introduction -- Basic rules of T cell migration -- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging -- Vascular normalization, T cell trafficking and anti-tumor immunity -- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts -- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic -- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy -- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors -- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors.
520 $a This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
650 0 $a Cancer $x Immunotherapy. $3 201873
650 0 $a T cells $x Therapeutic use. $3 758062
650 0 $a Drug resistance in cancer cells. $3 281104
650 1 4 $a Biomedicine. $3 273648
650 2 4 $a Cancer Research. $3 273660
650 2 4 $a Immunology. $3 189152
650 2 4 $a Molecular Medicine. $3 273932
700 1 $a Donnadieu, Emmanuel. $3 758061
710 2 $a SpringerLink (Online service) $3 273601
773 0 $t Springer eBooks
830 0 $a Resistance to targeted anti-cancer therapeutics. $3 699846
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-42223-7
950 $a Biomedical and Life Sciences (Springer-11642)