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Asthmatargeted biological therapies /

Maselli, Rosario.

Asthmatargeted biological therapies /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Asthmaby Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli.
Reminder of title:	targeted biological therapies /
Author:	Pelaia, Girolamo.
other author:	Vatrella, Alessandro.
Published:	Cham :Springer International Publishing :2017.
Description:	vi, 99 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	AsthmaTreatment.
Online resource:	http://dx.doi.org/10.1007/978-3-319-46007-9
ISBN:	9783319460079$q(electronic bk.)

Asthmatargeted biological therapies /
Pelaia, Girolamo.

Asthmatargeted biological therapies /[electronic resource] :by Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli. - Cham :Springer International Publishing :2017. - vi, 99 p. :ill., digital ;24 cm.

Introduction -- Inflammatory cellular patterns in asthma -- Airway remodelling in asthma -- Anti-IgE antibodies -- IL-5-targeted antibodies -- IL-4-specific biologics -- Anti-IL-13 therapies -- Anti-TNFalpha-antibodies -- Biologic treatments targeted to innate cytokines -- Other biologic drugs -- Conclusions and future perspectives.

This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.

ISBN: 9783319460079$q(electronic bk.)

Standard No.: 10.1007/978-3-319-46007-9doiSubjects--Topical Terms:

286234
Asthma
--Treatment.

LC Class. No.: RC591

Dewey Class. No.: 616.23806

Asthmatargeted biological therapies /
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245 1 0 $a Asthma $h [electronic resource] : $b targeted biological therapies / $c by Girolamo Pelaia, Alessandro Vatrella, Rosario Maselli.
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505 0 $a Introduction -- Inflammatory cellular patterns in asthma -- Airway remodelling in asthma -- Anti-IgE antibodies -- IL-5-targeted antibodies -- IL-4-specific biologics -- Anti-IL-13 therapies -- Anti-TNFalpha-antibodies -- Biologic treatments targeted to innate cytokines -- Other biologic drugs -- Conclusions and future perspectives.
520 $a This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.
650 0 $a Asthma $x Treatment. $3 286234
650 1 4 $a Medicine & Public Health. $3 273799
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650 2 4 $a Pharmacology/Toxicology. $3 273652
650 2 4 $a General Practice / Family Medicine. $3 274216
650 2 4 $a Pediatrics. $3 274247
700 1 $a Vatrella, Alessandro. $3 771426
700 1 $a Maselli, Rosario. $3 771427
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