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Leucine-Rich Repeat Kinase 2 (LRRK2)

Rideout, Hardy J.

Leucine-Rich Repeat Kinase 2 (LRRK2)

Record Type:	Electronic resources : Monograph/item
Title/Author:	Leucine-Rich Repeat Kinase 2 (LRRK2)edited by Hardy J. Rideout.
other author:	Rideout, Hardy J.
Published:	Cham :Springer International Publishing :2017.
Description:	xvii, 271 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Neurogenetics.
Online resource:	http://dx.doi.org/10.1007/978-3-319-49969-7
ISBN:	9783319499697$q(electronic bk.)

Leucine-Rich Repeat Kinase 2 (LRRK2)
Leucine-Rich Repeat Kinase 2 (LRRK2)[electronic resource] /edited by Hardy J. Rideout. - Cham :Springer International Publishing :2017. - xvii, 271 p. :ill., digital ;24 cm. - Advances in neurobiology,v.142190-5215 ;. - Advances in neurobiology ;v.4..

Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease -- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease -- Clinical features of LRRK2 carriers with Parkinson's disease -- Part II: Fundamentals of LRRK2 Biology -- LRRK2 phosphorylation -- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity -- LRRK2 and autophagy -- Molecular insights and functional implication of LRRK2 dimerization -- LRRK2 and the immune system -- Regulation of LRRK2 by phosphatases -- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options -- Animal models of LRRK2-associated Parkinson's disease -- LRRK2 and the "LRRKtosome" at the crossroads of programmed cell death: Clues from RIP kinase relatives -- Interaction of LRRK2 and α-synuclein in Parkinson's disease -- Mechanisms of mutant LRRK2 neurodegeneration -- Small molecule inhibitors of LRRK2.

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

ISBN: 9783319499697$q(electronic bk.)

Standard No.: 10.1007/978-3-319-49969-7doiSubjects--Topical Terms:

194455
Neurogenetics.

LC Class. No.: QP356.22

Dewey Class. No.: 612.8

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505 0 $a Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease -- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease -- Clinical features of LRRK2 carriers with Parkinson's disease -- Part II: Fundamentals of LRRK2 Biology -- LRRK2 phosphorylation -- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity -- LRRK2 and autophagy -- Molecular insights and functional implication of LRRK2 dimerization -- LRRK2 and the immune system -- Regulation of LRRK2 by phosphatases -- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options -- Animal models of LRRK2-associated Parkinson's disease -- LRRK2 and the "LRRKtosome" at the crossroads of programmed cell death: Clues from RIP kinase relatives -- Interaction of LRRK2 and α-synuclein in Parkinson's disease -- Mechanisms of mutant LRRK2 neurodegeneration -- Small molecule inhibitors of LRRK2.
520 $a This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
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