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Bone morphogenetic proteinssystems b...

Sampath, Kuber T.

Bone morphogenetic proteinssystems biology regulators /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Bone morphogenetic proteinsedited by Slobodan Vukicevic, Kuber T. Sampath.
其他題名:	systems biology regulators /
其他作者:	Vukicevic, Slobodan.
出版者:	Cham :Springer International Publishing :2017.
面頁冊數:	xii, 445 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
標題:	Bone morphogenetic proteins.
電子資源:	http://dx.doi.org/10.1007/978-3-319-47507-3
ISBN:	9783319475073$q(electronic bk.)

Bone morphogenetic proteinssystems biology regulators /
Bone morphogenetic proteinssystems biology regulators /[electronic resource] :edited by Slobodan Vukicevic, Kuber T. Sampath. - Cham :Springer International Publishing :2017. - xii, 445 p. :ill., digital ;24 cm. - Progress in inflammation research. - Progress in inflammation research..

Introduction -- BMPs: Historic and Future Perspectives -- BMP - Biology -- BMPs in Development -- BMP signaling -- BMP Antagonists - Biology -- BMP and BMP Antagonists - Structure and Function -- BMPs in Orthopaedic Medicine: Promises and Challenges -- BMP6 and Bone Repair -- BMPs in Dental Medicine: Promises and Challenges -- BMPs in Spine -- BMPs in Articular Joints -- BMP Signaling & FOP -- BMP-7 Biology and its Therapeutic Utility for Chronic Kidney Diseases -- BMPs in Inflammation -- BMPs and Angiogenesis -- BMP Signaling in Iron Homeostasis -- BMP Signaling in Pulmonary Arterial Hypertension -- BMP Signaling and Cancer -- BMP Biology in Rare Diseases.

This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.

ISBN: 9783319475073$q(electronic bk.)

Standard No.: 10.1007/978-3-319-47507-3doiSubjects--Topical Terms:

286355
Bone morphogenetic proteins.

LC Class. No.: QP552.B65

Dewey Class. No.: 612.751

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520 $a This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
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