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Biomedical applications of acridines...

Hlavacek, Jan.

Biomedical applications of acridinesderivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Biomedical applications of acridinesby Jan Jezek, Jan Hlavacek, Jaroslav Sebestik.
Reminder of title:	derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /
Author:	Jezek, Jan.
other author:	Hlavacek, Jan.
Published:	Cham :Springer International Publishing :2017.
Description:	xiii, 237 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Acridine.
Online resource:	http://dx.doi.org/10.1007/978-3-319-63953-6
ISBN:	9783319639536$q(electronic bk.)

Biomedical applications of acridinesderivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /
Jezek, Jan.

Biomedical applications of acridinesderivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /[electronic resource] :by Jan Jezek, Jan Hlavacek, Jaroslav Sebestik. - Cham :Springer International Publishing :2017. - xiii, 237 p. :ill., digital ;24 cm. - Progress in drug research,v.720071-786X ;. - Progress in drug research ;v.68..

Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.

ISBN: 9783319639536$q(electronic bk.)

Standard No.: 10.1007/978-3-319-63953-6doiSubjects--Topical Terms:

790773
Acridine.

LC Class. No.: QP551

Dewey Class. No.: 572.6

Biomedical applications of acridinesderivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases /
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245 1 0 $a Biomedical applications of acridines $h [electronic resource] : $b derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases / $c by Jan Jezek, Jan Hlavacek, Jaroslav Sebestik.
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490 1 $a Progress in drug research, $x 0071-786X ; $v v.72
505 0 $a Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.
520 $a This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
650 0 $a Acridine. $3 790773
650 1 4 $a Chemistry. $3 188628
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650 2 4 $a Protein-Ligand Interactions. $3 348845
650 2 4 $a Bioorganic Chemistry. $3 275016
650 2 4 $a Nucleic Acid Chemistry. $3 376665
700 1 $a Hlavacek, Jan. $3 790772
700 1 $a Sebestik, Jaroslav. $3 591956
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