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A network-based approach to cell met...

Guell, Oriol.

A network-based approach to cell metabolismfrom structure to flux balances /

Record Type:	Electronic resources : Monograph/item
Title/Author:	A network-based approach to cell metabolismby Oriol Guell.
Reminder of title:	from structure to flux balances /
Author:	Guell, Oriol.
Published:	Cham :Springer International Publishing :2017.
Description:	xx, 151 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Cell metabolism.
Online resource:	http://dx.doi.org/10.1007/978-3-319-64000-6
ISBN:	9783319640006$q(electronic bk.)

A network-based approach to cell metabolismfrom structure to flux balances /
Guell, Oriol.

A network-based approach to cell metabolismfrom structure to flux balances /[electronic resource] :by Oriol Guell. - Cham :Springer International Publishing :2017. - xx, 151 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Cellular Metabolism at the Systems Level -- Methods and Data -- Structural Knockout Cascades in Metabolic Networks -- Eﬀects of Reaction Knockouts on Steady States of Metabolism -- Detection of Evolution and Adaptation Fingerprints in Metabolic Networks -- Assessing FBA Optimal States in the Feasible Flux Phenotypic Space -- Conclusions.

This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions. Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec ts of the networks themselves to the balance of biochemical fluxes.

ISBN: 9783319640006$q(electronic bk.)

Standard No.: 10.1007/978-3-319-64000-6doiSubjects--Topical Terms:

345781
Cell metabolism.

LC Class. No.: QH634.5

Dewey Class. No.: 572.4

A network-based approach to cell metabolismfrom structure to flux balances /
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520 $a This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions. Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec ts of the networks themselves to the balance of biochemical fluxes.
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